Role of AT1 receptors in area postrema on baroreceptor reflex in spontaneously hypertensive rats

Kiyoshi Matsumura, David B. Averill, Carlos M. Ferrario

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Intravenous injection of angiotensin II type 1 (AT1) receptor antagonist improves the baroreceptor reflex gain in spontaneously hypertensive rats (SHRs). To investigate the role of area postrema in the modulation of the baroreflex control by AT1 receptor, the effects of intravenous injection of CV-11974 (AT1 receptor antagonist) on the baroreflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR) were examined in sham and area postrema-lesioned SHRs. The baseline mean arterial pressure was similar in both groups. However, baseline heart rate was significantly lower (p<0.01) in area postrema-lesioned SHR than in sham-lesioned SHR, 307±11 and 365±10 beats/min (bpm), respectively. Intravenous CV-11974 (0.05 mg/kg) significantly decreased mean arterial pressure; however, it did not change HR and RSNA in either group. Reflex changes in RSNA and HR were elicited by intravenous infusion of either phenylephrine or sodium nitroprusside before and after intravenous injection of CV-11974. Intravenous CV-11974 increased baroreflex control of RSNA (G(max); -1.57±0.08 vs. -1.92±0.12%/mmHg, p<0.05) and HR (G(max); -0.54±0.12 vs. 1.25±0.24 bpm/mmHg, p<0.05) in sham-lesioned SHRs. However, intravenous CV-11974 failed to alter the baroreflex sensitivities in area postrema-lesioned SHRs. These results suggest that the area postrema does not play a crucial role in maintenance of high blood pressure in adult SHRs, and that the improvement of baroreflex control of RSNA and HR by intravenous CV-11974 is mediated via the area postrema in SHRs. Copyright (C) 1999 Elsevier Science B.V.

元の言語英語
ページ(範囲)166-172
ページ数7
ジャーナルBrain Research
850
発行部数1-2
DOI
出版物ステータス出版済み - 12 11 1999

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Area Postrema
Angiotensin Type 1 Receptor
Baroreflex
Inbred SHR Rats
Heart Rate
Kidney
Intravenous Injections
Angiotensin II Type 1 Receptor Blockers
Arterial Pressure
Nitroprusside
Phenylephrine
Intravenous Infusions
Reflex
candesartan
Hypertension

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

これを引用

Role of AT1 receptors in area postrema on baroreceptor reflex in spontaneously hypertensive rats. / Matsumura, Kiyoshi; Averill, David B.; Ferrario, Carlos M.

:: Brain Research, 巻 850, 番号 1-2, 11.12.1999, p. 166-172.

研究成果: ジャーナルへの寄稿記事

Matsumura, Kiyoshi ; Averill, David B. ; Ferrario, Carlos M. / Role of AT1 receptors in area postrema on baroreceptor reflex in spontaneously hypertensive rats. :: Brain Research. 1999 ; 巻 850, 番号 1-2. pp. 166-172.
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abstract = "Intravenous injection of angiotensin II type 1 (AT1) receptor antagonist improves the baroreceptor reflex gain in spontaneously hypertensive rats (SHRs). To investigate the role of area postrema in the modulation of the baroreflex control by AT1 receptor, the effects of intravenous injection of CV-11974 (AT1 receptor antagonist) on the baroreflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR) were examined in sham and area postrema-lesioned SHRs. The baseline mean arterial pressure was similar in both groups. However, baseline heart rate was significantly lower (p<0.01) in area postrema-lesioned SHR than in sham-lesioned SHR, 307±11 and 365±10 beats/min (bpm), respectively. Intravenous CV-11974 (0.05 mg/kg) significantly decreased mean arterial pressure; however, it did not change HR and RSNA in either group. Reflex changes in RSNA and HR were elicited by intravenous infusion of either phenylephrine or sodium nitroprusside before and after intravenous injection of CV-11974. Intravenous CV-11974 increased baroreflex control of RSNA (G(max); -1.57±0.08 vs. -1.92±0.12{\%}/mmHg, p<0.05) and HR (G(max); -0.54±0.12 vs. 1.25±0.24 bpm/mmHg, p<0.05) in sham-lesioned SHRs. However, intravenous CV-11974 failed to alter the baroreflex sensitivities in area postrema-lesioned SHRs. These results suggest that the area postrema does not play a crucial role in maintenance of high blood pressure in adult SHRs, and that the improvement of baroreflex control of RSNA and HR by intravenous CV-11974 is mediated via the area postrema in SHRs. Copyright (C) 1999 Elsevier Science B.V.",
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