Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Eiki Takahashi; Kimie Niimi; Chitoshi Itakura

doi:10.1016/j.bbr.2010.12.019

Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

6 被引用数 (Scopus)

抄録

Heterozygous rolling Nagoya (rol/+) mice with a Ca_V2.1α₁ mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or Ca_V2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that Ca_V2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.

本文言語	英語
ページ（範囲）	353-356
ページ数	4
ジャーナル	Behavioural Brain Research
巻	218
号	2
DOI	https://doi.org/10.1016/j.bbr.2010.12.019
出版ステータス	出版済み - 4月 15 2011
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

行動神経科学

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10.1016/j.bbr.2010.12.019

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title = "Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory",

abstract = "Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.",

author = "Eiki Takahashi and Kimie Niimi and Chitoshi Itakura",

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T1 - Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

AU - Takahashi, Eiki

AU - Niimi, Kimie

AU - Itakura, Chitoshi

PY - 2011/4/15

Y1 - 2011/4/15

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AB - Heterozygous rolling Nagoya (rol/+) mice with a CaV2.1α1 mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5μg/side) or CaV2.1 inhibitor levetiracetam (0.1μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.

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Role of CaV2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory

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!!!All Science Journal Classification (ASJC) codes

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