Role of CCR2 in immunobiology and neurobiology

Ryo Yamasaki, Liping Liu, Jessica Lin, Richard M. Ransohoff

研究成果: Contribution to journalReview article査読

15 被引用数 (Scopus)

抄録

Chemokines and their receptors play crucial roles in the trafficking of leukocytes and are of particular interest in the context of the unique inflammatory responses elicited in the central nervous system (CNS). The chemokine receptor CCR2 and its ligand CCL2 have been implicated in a wide range of immunobiological processes and neuropathologies, including recruitment of monocytes and regulation of bone marrow homeostasis, as well as multiple sclerosis, HIV-associated dementia, Alzheimer's disease and neuropathic pain. Recently, powerful biological tools (CCR2-red fluorescent protein [RFP] knock-in mice) have been developed to analyze the functions of CCR2 in different cell populations, and intriguing results have emerged from those mice. The present review emphasizes CCR2/CCL2 as a key chemokine/chemokine receptor pair that controls the recruitment or retention of a key subset of mononuclear phagocytes in inflammation associated with host defense or disease.

本文言語英語
ページ(範囲)16-29
ページ数14
ジャーナルClinical and Experimental Neuroimmunology
3
1
DOI
出版ステータス出版済み - 1 1 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(その他)
  • 免疫学
  • 免疫学および微生物学(その他)
  • 臨床神経学

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