[Role of chronic inflammation in adipose tissue in the pathophysiology of obesity].

Takayoshi Suganami, Yoshihiro Ogawa

研究成果: Contribution to journalReview article

3 引用 (Scopus)

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Obesity may be viewed as a chronic low-grade inflammatory disease as well as a metabolic disease. Evidence has accumulated suggesting that chronic inflammation in adipose tissue leads to dramatic changes in number and cell type of stromal cells during the course of obesity, which is referred to as"adipose tissue remodeling". Among stromal cells, macrophages in obese adipose tissue are considered to be crucial for adipose tissue inflammation, which results in dysregulated adipocytokine production and ectopic fat accumulation. Understanding the molecular mechanism underlying adipose tissue inflammation would contribute to the identification of novel therapeutic strategies to prevent or treat obesity-induced metabolic derangements.

元の言語英語
ページ(範囲)225-230
ページ数6
ジャーナルUnknown Journal
71
発行部数2
出版物ステータス出版済み - 1 1 2013
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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