Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells

Shigeru Sugiyama, Kazuhiko Nakabayashi, Iwai Baba, Takehiko Sasazuki, Senji Shirasawa

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

We have previously found that epiregulin, a member of epidermal growth factor superfamily, is involved in proinflammatory cytokine production in bone marrow-derived macrophages. In this report, to further assess the role of epiregulin in innate immunity, we measured IL-6 production levels upon lipopolysaccharide and peptidoglycan stimulation in antigen presenting cells including macrophages and dendritic cells. Our analyses using epiregulin-deficient mice with mixed and inbred genetic backgrounds revealed that epiregulin deficiency results in the reduction of IL-6 production levels in both cell types upon peptidoglycan stimulation, and that the extent of this reduction is more evident under the BALB/c background compared with the C57BL/6J background. These results indicated that epiregulin may have a critical role in the regulation of peptidoglycan-mediated proinflammatory cytokine production in antigen presenting cells and innate immunity.

元の言語英語
ページ(範囲)271-274
ページ数4
ジャーナルBiochemical and Biophysical Research Communications
337
発行部数1
DOI
出版物ステータス出版済み - 11 11 2005
外部発表Yes

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Peptidoglycan
Antigen-Presenting Cells
Cytokines
Macrophages
Innate Immunity
Interleukin-6
Epidermal Growth Factor
Dendritic Cells
Lipopolysaccharides
Bone
Epiregulin

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. / Sugiyama, Shigeru; Nakabayashi, Kazuhiko; Baba, Iwai; Sasazuki, Takehiko; Shirasawa, Senji.

:: Biochemical and Biophysical Research Communications, 巻 337, 番号 1, 11.11.2005, p. 271-274.

研究成果: ジャーナルへの寄稿記事

Sugiyama, Shigeru ; Nakabayashi, Kazuhiko ; Baba, Iwai ; Sasazuki, Takehiko ; Shirasawa, Senji. / Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. :: Biochemical and Biophysical Research Communications. 2005 ; 巻 337, 番号 1. pp. 271-274.
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