Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage

Kouji Kobiyama, Akira Kawashima, Nao Jounai, Fumihiko Takeshita, Ken J. Ishii, Tetsuhide Ito, Koichi Suzuki

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Histones are essential components of chromatin structure, and histone modification plays an important role in various cellular functions including transcription, gene silencing, and immunity. Histones also play distinct roles in extrachromosomal settings. Extrachromosomal histone H2B acts as a cytosolic sensor to detect double-stranded DNA (dsDNA) fragments derived from infectious agents or damaged cells to activate innate and acquired immune responses in various cell types. It also physically interacts with interferon (IFN)-β promoter stimulator 1 (IPS-1), an essential adaptor molecule that activates innate immunity, through COOH-terminal importin 9-related adaptor organizing histone H2B and IPS-1 (CIAO), resulting in a distinct signaling complex that induces dsDNA-induced type I IFN production. Such a molecular platform acts a a cellular sensor to recognize aberrant dsDNA in cases of viral infection and cell damage. This mechanism may also play roles in autoimmunity, transplantation rejection, gene-mediated vaccines, and other therapeutic applications.

本文言語英語
論文番号Article 91
ジャーナルFrontiers in Genetics
4
MAY
DOI
出版ステータス出版済み - 2013

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 遺伝学
  • 遺伝学(臨床)

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