Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.

S. Takeishi, K. I. Nakayama

研究成果: Contribution to journalReview article査読

44 被引用数 (Scopus)

抄録

In addition to the properties of self-renewal and multipotency, stem cells are characterised by their distinct cell cycle status. Somatic stem cells are maintained in a quiescent state but switch reversibly from quiescence to proliferation as needed. On the other hand, embryonic stem cells and induced pluripotent stem cells proliferate rapidly until the induction of differentiation results in inhibition of cell cycle progression. Uncovering the mechanisms underlying cell cycle control in stem cells should thus provide insight into regulation of the balance between self-renewal and differentiation, a key goal of stem cell biology. Recent research has shown that cancer-initiating cells (CICs), a cell population with stem cell-like properties in cancer, are also quiescent, with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of the mechanisms of CIC quiescence might therefore be expected to provide a basis for the eradication of cancer. This review summarises our current understanding of the role of F-box and WD40 repeat domain-containing 7 (Fbxw7), a key regulator of the cell cycle, in the maintenance of normal stem cells and CICs, as well as attempts to define future challenges in this field.

本文言語英語
ページ(範囲)1054-1059
ページ数6
ジャーナルBritish journal of cancer
111
6
DOI
出版ステータス出版済み - 9 9 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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