Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein

Y. Esaki, Y. Fukui, T. Sudo, K. Yamamoto, T. Inamitsu, Y. Nishimura, K. Hirokawa, A. Kimura, T. Sasazuki

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Antigenicity of peptic extract from type 12 group A streptococci (PEAST12) for T cells was examined in major histocompatibility complex (MHC) class II transgenic mice. PEAST12 was mitogenic for murine T cells when antigen- presenting cells were obtained from human MHC (HLA)-DQ4αβ transgenic mice or from DQ6αβ transgenic mice but was not mitogenic in DRα transgenic, DR51αβ transgenic, Eα transgenic, or nontransgenic mice. In addition, PEAST12 showed mitogenicity for murine T cells in DQ4α singly transgenic mice but not in DQ4β singly transgenic mice. T-cell stimulation by PEAST12 was unrestricted by but dependent on the expression of HLA-DQ molecules on antigen-presenting cells, and PEAST12 selectively activated T-cell receptor Vβ11-, Vβ15-, and Vβ18-positive T cells in mice. We propose that PEAST12 contains a superantigen which binds preferentially to the α-chain of HLA-DQ molecules. The well-known phenomenon that peptic extracts from group A streptococci are mitogenic in humans but not in mice is likely due to structural differences in MHC class II molecules between these two species of mammals.

元の言語英語
ページ(範囲)1228-1235
ページ数8
ジャーナルInfection and Immunity
62
発行部数4
出版物ステータス出版済み - 1 1 1994

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Streptococcus
Major Histocompatibility Complex
Transgenic Mice
T-Lymphocytes
HLA-DQ Antigens
Antigen-Presenting Cells
Proteins
Digestion
Superantigens
T-Cell Antigen Receptor
Mammals

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

これを引用

Esaki, Y., Fukui, Y., Sudo, T., Yamamoto, K., Inamitsu, T., Nishimura, Y., ... Sasazuki, T. (1994). Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein. Infection and Immunity, 62(4), 1228-1235.

Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein. / Esaki, Y.; Fukui, Y.; Sudo, T.; Yamamoto, K.; Inamitsu, T.; Nishimura, Y.; Hirokawa, K.; Kimura, A.; Sasazuki, T.

:: Infection and Immunity, 巻 62, 番号 4, 01.01.1994, p. 1228-1235.

研究成果: ジャーナルへの寄稿記事

Esaki, Y, Fukui, Y, Sudo, T, Yamamoto, K, Inamitsu, T, Nishimura, Y, Hirokawa, K, Kimura, A & Sasazuki, T 1994, 'Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein', Infection and Immunity, 巻. 62, 番号 4, pp. 1228-1235.
Esaki, Y. ; Fukui, Y. ; Sudo, T. ; Yamamoto, K. ; Inamitsu, T. ; Nishimura, Y. ; Hirokawa, K. ; Kimura, A. ; Sasazuki, T. / Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein. :: Infection and Immunity. 1994 ; 巻 62, 番号 4. pp. 1228-1235.
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