Role of LRF/Pokemon in lineage fate decisions

Andrea Lunardi, Jlenia Guarnerio, Guocan Wang, Takahiro Maeda, Pier Paolo Pandolfi

研究成果: Contribution to journalReview article査読

44 被引用数 (Scopus)

抄録

In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.

本文言語英語
ページ(範囲)2845-2853
ページ数9
ジャーナルBlood
121
15
DOI
出版ステータス出版済み - 4 11 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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