Role of microtubules in the transition from compensated cardiac hypertrophy to failure

Hiroyuki Tsutsui, Hirofumi Tagawa, George Cooper IV, Akira Takeshita

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

Cardiac hypertrophy in response to systolic pressure overloading results in myocyte contractile dysfunction, the mechanisms for which have not been established. Stress loading increases the microtubules, which apparently is responsible for the cellular contractile dysfunction. These alterations in microtubules and contractile function have a specific association with increased ventricular wall stress. The linked microtubule and contractile abnormalities are persistent and the further increase of microtubules plays an important role in the deterioration of initially compensated cardiac hypertrophy into heart failure.

本文言語英語
ページ(範囲)311-318
ページ数8
ジャーナルHeart Failure Reviews
4
4
DOI
出版ステータス出版済み - 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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