Role of mitochondrial p32 in dendritic cell maturation

研究成果: Contribution to journalArticle査読

抄録

Dendritic cells (DCs) are the most potent antigen-presenting cells and have a unique ability to induce primary immune responses. DC maturation induced by Toll-like receptor (TLR) agonists requires activation of downstream signal transduction and metabolic changes. DCs activated via TLRs have central roles mitochondrial matrix. p32/Clqbp is required for appropriate interleukin (IL)-6 production upon lipopolysaccharide (LPS) stimulation. However, the exact mechanisms of p32 functions in DCs remain unclear. In this review, we discuss p32-dependent metabolic pathway during DC activation.

本文言語英語
ページ(範囲)117-123
ページ数7
ジャーナルJapanese Journal of Clinical Chemistry
49
2
出版ステータス出版済み - 2020

All Science Journal Classification (ASJC) codes

  • 臨床生化学

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