Role of potassium channels in cerebral blood vessels

Takanari Kitazono, Frank M. Faraci, Hisao Taguchi, Donald D. Heistad

研究成果: Contribution to journalReview article査読

157 被引用数 (Scopus)

抄録

Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels. Summary of ReviewActivation of ATP-sensitive and calcium-activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis. ConclusionsActivation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.

本文言語英語
ページ(範囲)1713-1723
ページ数11
ジャーナルStroke
26
9
DOI
出版ステータス出版済み - 9 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 臨床神経学
  • 循環器および心血管医学
  • 高度および特殊看護

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