Role of pulmonary metastasectomy in colorectal cancer in the era of modern multidisciplinary therapy

Ryu Kanzaki, Masayoshi Inoue, Toru Kimura, Tomohiro Kawamura, Soichiro Funaki, Yasushi Shintani, Masato Minami, Ichiro Takemasa, Tsunekazu Mizushima, Masaki Mori, Meinoshin Okumura

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Purpose: To clarify the role of pulmonary metastasectomy in colorectal cancer in the era of modern multidisciplinary therapy. Methods: The characteristics and outcomes of the patients who underwent pulmonary metastasectomy for colorectal cancer through 2002 (n = 26) and from 2003 (n = 68) were compared. Results: The patients treated from 2003 had a smaller tumor size and more frequently had a history of extra-pulmonary relapses than did those treated through 2002. There was a significant improvement in the 5-year overall survival (42.0% vs. 73.1%, p = 0.03) but not the 5-year relapse-free survival (41.4% vs. 37.5%, p = 0.85) after pulmonary metastasectomy from 2003. The rate of patients who received local therapy with curative intent after the first pulmonary metastasectomy was significantly higher in patients treated from 2003 than in those treated through 2002 [4/13, (31%) vs. 25/39 (64%), p = 0.04]. The survival after relapse after the first pulmonary metastasectomy was significantly longer in patients treated from 2003 than in those treated through 2002 (median survival time: 14 vs. 47 months). Conclusions: Pulmonary metastasectomy for colorectal cancer remains an important treatment option in the sense that it can achieve a good relapse-free survival.

本文言語英語
ページ(範囲)1111-1118
ページ数8
ジャーナルSurgery today
47
9
DOI
出版ステータス出版済み - 9 1 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • Surgery

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