Role of SpyGlass-DS tm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct

Ohtsuka Takao, Yoshitaka Gotoh, Yohei Nakashima, Yoshifumi Okayama, So Nakamura, Makiko Morita, Mohammed Yahia Farrag Aly, Vittoria Vanessa D.M. Velasquez, Yasuhisa Mori, Yoshihiko Sadakari, Kohei Nakata, Yoshihiro Miyasaka, Kosei Ishigami, Nao Fujimori, Naoki Mochidome, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura

研究成果: ジャーナルへの寄稿記事

抄録

Background/Objectives: It is often difficult to determine an adequate resection line during pancreatectomy for intraductal papillary mucinous neoplasm involving the main pancreatic duct during partial pancreatectomy. The aim of this study was to evaluate the usefulness of improved peroral pancreatoscopy using SpyGlass-DS tm in the preoperative assessment of intraductal papillary mucinous neoplasm involving the main pancreatic duct. Methods: We collected and retrospectively analyzed clinicopathological data from seven consecutive patients who underwent preoperative assessment of intraductal papillary mucinous neoplasm involving the main duct using SpyGlass-DS tm . Results: Good imaging quality of the intraductal protruding lesion was obtained in all seven patients, and only one adverse event was noted wherein a patient had mild pancreatitis. Six patients underwent pancreatectomy. In one patient, masked-type concomitant pancreatic ductal adenocarcinoma and low-length dysplastic lesion was found near the surgical margin, which was not detected by preoperative imaging modalities including SpyGlass-DS tm . The sensitivity of targeting biopsy during SpyGlass-DS tm to diagnose high-grade dysplasia was 0%. Conclusions: SpyGlass-DS tm can be safely performed in patients with intraductal papillary mucinous neoplasm involving the main duct, and has excellent visualization of the target lesion. However, challenges include poor diagnostic ability of targeting biopsy, and, therefore, intraoperative frozen section is still needed to obtain negative surgical margins.

元の言語英語
ページ(範囲)566-571
ページ数6
ジャーナルPancreatology
18
発行部数5
DOI
出版物ステータス出版済み - 7 1 2018

Fingerprint

Pancreatic Ducts
Pancreatectomy
Neoplasms
Biopsy
Frozen Sections
Pancreatitis
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

これを引用

Role of SpyGlass-DS tm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct . / Takao, Ohtsuka; Gotoh, Yoshitaka; Nakashima, Yohei; Okayama, Yoshifumi; Nakamura, So; Morita, Makiko; Aly, Mohammed Yahia Farrag; Velasquez, Vittoria Vanessa D.M.; Mori, Yasuhisa; Sadakari, Yoshihiko; Nakata, Kohei; Miyasaka, Yoshihiro; Ishigami, Kosei; Fujimori, Nao; Mochidome, Naoki; Oda, Yoshinao; Shimizu, Shuji; Nakamura, Masafumi.

:: Pancreatology, 巻 18, 番号 5, 01.07.2018, p. 566-571.

研究成果: ジャーナルへの寄稿記事

Takao, O, Gotoh, Y, Nakashima, Y, Okayama, Y, Nakamura, S, Morita, M, Aly, MYF, Velasquez, VVDM, Mori, Y, Sadakari, Y, Nakata, K, Miyasaka, Y, Ishigami, K, Fujimori, N, Mochidome, N, Oda, Y, Shimizu, S & Nakamura, M 2018, ' Role of SpyGlass-DS tm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct ', Pancreatology, 巻. 18, 番号 5, pp. 566-571. https://doi.org/10.1016/j.pan.2018.04.012
Takao, Ohtsuka ; Gotoh, Yoshitaka ; Nakashima, Yohei ; Okayama, Yoshifumi ; Nakamura, So ; Morita, Makiko ; Aly, Mohammed Yahia Farrag ; Velasquez, Vittoria Vanessa D.M. ; Mori, Yasuhisa ; Sadakari, Yoshihiko ; Nakata, Kohei ; Miyasaka, Yoshihiro ; Ishigami, Kosei ; Fujimori, Nao ; Mochidome, Naoki ; Oda, Yoshinao ; Shimizu, Shuji ; Nakamura, Masafumi. / Role of SpyGlass-DS tm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct :: Pancreatology. 2018 ; 巻 18, 番号 5. pp. 566-571.
@article{c9b27e41ce784f9299b6bee92c8ddeff,
title = "Role of SpyGlass-DS tm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct",
abstract = "Background/Objectives: It is often difficult to determine an adequate resection line during pancreatectomy for intraductal papillary mucinous neoplasm involving the main pancreatic duct during partial pancreatectomy. The aim of this study was to evaluate the usefulness of improved peroral pancreatoscopy using SpyGlass-DS tm in the preoperative assessment of intraductal papillary mucinous neoplasm involving the main pancreatic duct. Methods: We collected and retrospectively analyzed clinicopathological data from seven consecutive patients who underwent preoperative assessment of intraductal papillary mucinous neoplasm involving the main duct using SpyGlass-DS tm . Results: Good imaging quality of the intraductal protruding lesion was obtained in all seven patients, and only one adverse event was noted wherein a patient had mild pancreatitis. Six patients underwent pancreatectomy. In one patient, masked-type concomitant pancreatic ductal adenocarcinoma and low-length dysplastic lesion was found near the surgical margin, which was not detected by preoperative imaging modalities including SpyGlass-DS tm . The sensitivity of targeting biopsy during SpyGlass-DS tm to diagnose high-grade dysplasia was 0{\%}. Conclusions: SpyGlass-DS tm can be safely performed in patients with intraductal papillary mucinous neoplasm involving the main duct, and has excellent visualization of the target lesion. However, challenges include poor diagnostic ability of targeting biopsy, and, therefore, intraoperative frozen section is still needed to obtain negative surgical margins.",
author = "Ohtsuka Takao and Yoshitaka Gotoh and Yohei Nakashima and Yoshifumi Okayama and So Nakamura and Makiko Morita and Aly, {Mohammed Yahia Farrag} and Velasquez, {Vittoria Vanessa D.M.} and Yasuhisa Mori and Yoshihiko Sadakari and Kohei Nakata and Yoshihiro Miyasaka and Kosei Ishigami and Nao Fujimori and Naoki Mochidome and Yoshinao Oda and Shuji Shimizu and Masafumi Nakamura",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.pan.2018.04.012",
language = "English",
volume = "18",
pages = "566--571",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Role of SpyGlass-DS tm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct

AU - Takao, Ohtsuka

AU - Gotoh, Yoshitaka

AU - Nakashima, Yohei

AU - Okayama, Yoshifumi

AU - Nakamura, So

AU - Morita, Makiko

AU - Aly, Mohammed Yahia Farrag

AU - Velasquez, Vittoria Vanessa D.M.

AU - Mori, Yasuhisa

AU - Sadakari, Yoshihiko

AU - Nakata, Kohei

AU - Miyasaka, Yoshihiro

AU - Ishigami, Kosei

AU - Fujimori, Nao

AU - Mochidome, Naoki

AU - Oda, Yoshinao

AU - Shimizu, Shuji

AU - Nakamura, Masafumi

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background/Objectives: It is often difficult to determine an adequate resection line during pancreatectomy for intraductal papillary mucinous neoplasm involving the main pancreatic duct during partial pancreatectomy. The aim of this study was to evaluate the usefulness of improved peroral pancreatoscopy using SpyGlass-DS tm in the preoperative assessment of intraductal papillary mucinous neoplasm involving the main pancreatic duct. Methods: We collected and retrospectively analyzed clinicopathological data from seven consecutive patients who underwent preoperative assessment of intraductal papillary mucinous neoplasm involving the main duct using SpyGlass-DS tm . Results: Good imaging quality of the intraductal protruding lesion was obtained in all seven patients, and only one adverse event was noted wherein a patient had mild pancreatitis. Six patients underwent pancreatectomy. In one patient, masked-type concomitant pancreatic ductal adenocarcinoma and low-length dysplastic lesion was found near the surgical margin, which was not detected by preoperative imaging modalities including SpyGlass-DS tm . The sensitivity of targeting biopsy during SpyGlass-DS tm to diagnose high-grade dysplasia was 0%. Conclusions: SpyGlass-DS tm can be safely performed in patients with intraductal papillary mucinous neoplasm involving the main duct, and has excellent visualization of the target lesion. However, challenges include poor diagnostic ability of targeting biopsy, and, therefore, intraoperative frozen section is still needed to obtain negative surgical margins.

AB - Background/Objectives: It is often difficult to determine an adequate resection line during pancreatectomy for intraductal papillary mucinous neoplasm involving the main pancreatic duct during partial pancreatectomy. The aim of this study was to evaluate the usefulness of improved peroral pancreatoscopy using SpyGlass-DS tm in the preoperative assessment of intraductal papillary mucinous neoplasm involving the main pancreatic duct. Methods: We collected and retrospectively analyzed clinicopathological data from seven consecutive patients who underwent preoperative assessment of intraductal papillary mucinous neoplasm involving the main duct using SpyGlass-DS tm . Results: Good imaging quality of the intraductal protruding lesion was obtained in all seven patients, and only one adverse event was noted wherein a patient had mild pancreatitis. Six patients underwent pancreatectomy. In one patient, masked-type concomitant pancreatic ductal adenocarcinoma and low-length dysplastic lesion was found near the surgical margin, which was not detected by preoperative imaging modalities including SpyGlass-DS tm . The sensitivity of targeting biopsy during SpyGlass-DS tm to diagnose high-grade dysplasia was 0%. Conclusions: SpyGlass-DS tm can be safely performed in patients with intraductal papillary mucinous neoplasm involving the main duct, and has excellent visualization of the target lesion. However, challenges include poor diagnostic ability of targeting biopsy, and, therefore, intraoperative frozen section is still needed to obtain negative surgical margins.

UR - http://www.scopus.com/inward/record.url?scp=85046799975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046799975&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2018.04.012

DO - 10.1016/j.pan.2018.04.012

M3 - Article

VL - 18

SP - 566

EP - 571

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 5

ER -