TY - JOUR
T1 - Role of the P2X4 receptor in neuropathic pain
AU - Inoue, Kazuhide
N1 - Funding Information:
This work was supported partly by JSPS KAKENHI Grant Numbers 25117013 and the Core Research for Evolutional Science and Technology (AMED-CREST) program from Japan Agency for Medical Research and Development. I also thank Prof. Makoto Tsuda and many students for the experiments.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/8
Y1 - 2019/8
N2 - Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, play a principal role in evoking this pain. Understanding the functions of microglial P2X4R in evoking this pain provides potential strategies for developing new treatments for neuropathic pain.
AB - Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, play a principal role in evoking this pain. Understanding the functions of microglial P2X4R in evoking this pain provides potential strategies for developing new treatments for neuropathic pain.
UR - http://www.scopus.com/inward/record.url?scp=85062840471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062840471&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2019.02.001
DO - 10.1016/j.coph.2019.02.001
M3 - Review article
C2 - 30878800
AN - SCOPUS:85062840471
VL - 47
SP - 33
EP - 39
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
ER -