Role of troponin C in determining the Ca2+-sensitivity and cooperativity of the tension development in rabbit skeletal and cardiac muscles1

Sachio Morimoto, Iwao Ohtsuki

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

The role of troponin C in determining the characteristic differences in contraction between fast-twitch skeletal and cardiac muscles was investigated with rabbit skinned psoas fibers and left ventricular trabeculae by exchanging their troponins C using a technique involving extraction and replacement. In both muscle types, skeletal troponin C conferred higher cooperativity on the Ca2+-activated tension development than cardiac troponin C, indicating that troponin C plays a crucial role in determining the cooperativity in Ca2+ activation of vertebrate striated muscle. Furthermore, the foreign type of troponin C was found to confer lower Ca2+sensitivity on the tension development in both fast-twitch skeletal and cardiac muscles than the native type of troponin C. This indicates that the Ca2+sensitivity of each muscle type is determined by troponin C interactions with other troponin subunits and not by troponin C alone.

本文言語英語
ページ(範囲)144-146
ページ数3
ジャーナルJournal of biochemistry
115
1
DOI
出版ステータス出版済み - 1 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

フィンガープリント 「Role of troponin C in determining the Ca<sup>2+</sup>-sensitivity and cooperativity of the tension development in rabbit skeletal and cardiac muscles<sup>1</sup>」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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