Role of tumor-associated macrophages in the progression of hepatocellular carcinoma

Ken Shirabe, Yohei Mano, Jun Muto, Rumi Matono, Takashi Motomura, Takeo Toshima, kazuki takeishi, Hidekaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Masaru Morita, Shunichi Tsujitani, Yoshihisa Sakaguchi, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿評論記事

77 引用 (Scopus)

抄録

Recent studies have shown that the tumor microenvironment plays an important role in cancer progression. Tumor-associated macrophages (TAMs), in particular, have been found to be associated with tumor progression. Macrophages have multiple biological roles, including antigen presentation, target cell cytotoxicity, removal of foreign bodies, tissue remodeling, regulation of inflammation, induction of immunity, thrombosis, and endocytosis. Recent immunological studies have identified two distinct states of polarized macrophage activation: the classically activated (M1) and the alternatively activated (M2) macrophage phenotypes. Bacterial moieties such as lipopolysaccharides and the Th1 cytokine interferon-γ polarize macrophages toward the M1 phenotype. The M2 polarization was discovered as a response to the Th2 cytokine interleukin-4. In general, M2 macrophages exert immunoregulatory activity, participate in polarized Th2 responses, and aid tumor progression. TAMs have recently been found to play an important role in hepatocellular carcinoma (HCC) progression. Based on the properties of TAMs, obtained from pathological examination of resected specimens, we have identified new therapeutic approaches, involving the targeting of TAMs with adjuvant therapy after hepatic resection for HCC. This review discusses the roles of TAM in HCC progression and the possibility of new therapies targeting TAMs.

元の言語英語
ページ(範囲)1-7
ページ数7
ジャーナルSurgery today
42
発行部数1
DOI
出版物ステータス出版済み - 1 1 2012

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Hepatocellular Carcinoma
Macrophages
Neoplasms
Cytokines
Phenotype
Tumor Microenvironment
Macrophage Activation
Antigen Presentation
Endocytosis
Foreign Bodies
Interleukin-4
Interferons
Lipopolysaccharides
Immunity
Thrombosis
Therapeutics
Inflammation
Liver

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Shirabe, K., Mano, Y., Muto, J., Matono, R., Motomura, T., Toshima, T., ... Maehara, Y. (2012). Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. Surgery today, 42(1), 1-7. https://doi.org/10.1007/s00595-011-0058-8

Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. / Shirabe, Ken; Mano, Yohei; Muto, Jun; Matono, Rumi; Motomura, Takashi; Toshima, Takeo; takeishi, kazuki; Uchiyama, Hidekaki; Yoshizumi, Tomoharu; Taketomi, Akinobu; Morita, Masaru; Tsujitani, Shunichi; Sakaguchi, Yoshihisa; Maehara, Yoshihiko.

:: Surgery today, 巻 42, 番号 1, 01.01.2012, p. 1-7.

研究成果: ジャーナルへの寄稿評論記事

Shirabe, K, Mano, Y, Muto, J, Matono, R, Motomura, T, Toshima, T, takeishi, K, Uchiyama, H, Yoshizumi, T, Taketomi, A, Morita, M, Tsujitani, S, Sakaguchi, Y & Maehara, Y 2012, 'Role of tumor-associated macrophages in the progression of hepatocellular carcinoma', Surgery today, 巻. 42, 番号 1, pp. 1-7. https://doi.org/10.1007/s00595-011-0058-8
Shirabe K, Mano Y, Muto J, Matono R, Motomura T, Toshima T その他. Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. Surgery today. 2012 1 1;42(1):1-7. https://doi.org/10.1007/s00595-011-0058-8
Shirabe, Ken ; Mano, Yohei ; Muto, Jun ; Matono, Rumi ; Motomura, Takashi ; Toshima, Takeo ; takeishi, kazuki ; Uchiyama, Hidekaki ; Yoshizumi, Tomoharu ; Taketomi, Akinobu ; Morita, Masaru ; Tsujitani, Shunichi ; Sakaguchi, Yoshihisa ; Maehara, Yoshihiko. / Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. :: Surgery today. 2012 ; 巻 42, 番号 1. pp. 1-7.
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abstract = "Recent studies have shown that the tumor microenvironment plays an important role in cancer progression. Tumor-associated macrophages (TAMs), in particular, have been found to be associated with tumor progression. Macrophages have multiple biological roles, including antigen presentation, target cell cytotoxicity, removal of foreign bodies, tissue remodeling, regulation of inflammation, induction of immunity, thrombosis, and endocytosis. Recent immunological studies have identified two distinct states of polarized macrophage activation: the classically activated (M1) and the alternatively activated (M2) macrophage phenotypes. Bacterial moieties such as lipopolysaccharides and the Th1 cytokine interferon-γ polarize macrophages toward the M1 phenotype. The M2 polarization was discovered as a response to the Th2 cytokine interleukin-4. In general, M2 macrophages exert immunoregulatory activity, participate in polarized Th2 responses, and aid tumor progression. TAMs have recently been found to play an important role in hepatocellular carcinoma (HCC) progression. Based on the properties of TAMs, obtained from pathological examination of resected specimens, we have identified new therapeutic approaches, involving the targeting of TAMs with adjuvant therapy after hepatic resection for HCC. This review discusses the roles of TAM in HCC progression and the possibility of new therapies targeting TAMs.",
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AU - Taketomi, Akinobu

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