Roles of Epigenetics in the Neural Stem Cell and Neuron

Naoki Yamamoto, Masahiro Uesaka, Takuya Imamura, Kinichi Nakashima

研究成果: 著書/レポートタイプへの貢献

抄録

For higher-order functions of the mammalian brain such as the regulation of motor behavior, consciousness, emotion, learning, and memory, neurons have to establish complicated and elaborate networks. In addition, the functions of neurons are critically supported by glial cells (astrocytes and oligodendrocytes). All of these neural cell types (i.e., neurons, astrocytes, and oligodendrocytes) are generated from common neural stem cells (NSCs), which also have self-renewal activity. Accumulating evidence suggests that the behavior of NSCs is influenced spatiotemporally by both cell-extrinsic factors, including cytokine signaling, and cell-intrinsic epigenetic changes, which together regulate the proliferation and fate decisions of NSCs to produce glial cells or neurons, including different neuronal subtypes, in a spatiotemporal manner. In the first half of this chapter, we summarize recent advances in elucidating the role of epigenetic control in the differentiation of NSCs. In postmitotic neurons, as well as NSCs, several orchestrated epigenetic mechanisms underlie neuronal functioning critical for memory formation. Recent studies have revealed the presence and physiological significance of changes of the epigenetic modifications within a neuron of an already defined cell fate. A dynamic change of epigenetic status induced by neuronal activity can alter synaptic plasticity, which constitutes part of the mechanisms of learning and memory. In the latter half of the chapter, we describe the role of epigenetic plasticity in non-dividing neurons. We also discuss the robust identity of the neuronal cell fate, as exemplified by the extremely poor ability of neurons to be reprogrammed to pluripotent stem cells.

元の言語英語
ホスト出版物のタイトルEpigenetics in Psychiatry
出版者Elsevier Inc.
ページ51-78
ページ数28
ISBN(電子版)9780124171343
ISBN(印刷物)9780124171145
DOI
出版物ステータス出版済み - 6 20 2014

Fingerprint

Neural Stem Cells
Epigenomics
Neurons
Oligodendroglia
Neuroglia
Astrocytes
Learning
Pluripotent Stem Cells
Neuronal Plasticity
Aptitude
Consciousness
Emotions
Cytokines
Brain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Yamamoto, N., Uesaka, M., Imamura, T., & Nakashima, K. (2014). Roles of Epigenetics in the Neural Stem Cell and Neuron. : Epigenetics in Psychiatry (pp. 51-78). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-417114-5.00004-8

Roles of Epigenetics in the Neural Stem Cell and Neuron. / Yamamoto, Naoki; Uesaka, Masahiro; Imamura, Takuya; Nakashima, Kinichi.

Epigenetics in Psychiatry. Elsevier Inc., 2014. p. 51-78.

研究成果: 著書/レポートタイプへの貢献

Yamamoto, N, Uesaka, M, Imamura, T & Nakashima, K 2014, Roles of Epigenetics in the Neural Stem Cell and Neuron. : Epigenetics in Psychiatry. Elsevier Inc., pp. 51-78. https://doi.org/10.1016/B978-0-12-417114-5.00004-8
Yamamoto, Naoki ; Uesaka, Masahiro ; Imamura, Takuya ; Nakashima, Kinichi. / Roles of Epigenetics in the Neural Stem Cell and Neuron. Epigenetics in Psychiatry. Elsevier Inc., 2014. pp. 51-78
@inbook{6011f339629c4237bcf930cb5a5aafb0,
title = "Roles of Epigenetics in the Neural Stem Cell and Neuron",
abstract = "For higher-order functions of the mammalian brain such as the regulation of motor behavior, consciousness, emotion, learning, and memory, neurons have to establish complicated and elaborate networks. In addition, the functions of neurons are critically supported by glial cells (astrocytes and oligodendrocytes). All of these neural cell types (i.e., neurons, astrocytes, and oligodendrocytes) are generated from common neural stem cells (NSCs), which also have self-renewal activity. Accumulating evidence suggests that the behavior of NSCs is influenced spatiotemporally by both cell-extrinsic factors, including cytokine signaling, and cell-intrinsic epigenetic changes, which together regulate the proliferation and fate decisions of NSCs to produce glial cells or neurons, including different neuronal subtypes, in a spatiotemporal manner. In the first half of this chapter, we summarize recent advances in elucidating the role of epigenetic control in the differentiation of NSCs. In postmitotic neurons, as well as NSCs, several orchestrated epigenetic mechanisms underlie neuronal functioning critical for memory formation. Recent studies have revealed the presence and physiological significance of changes of the epigenetic modifications within a neuron of an already defined cell fate. A dynamic change of epigenetic status induced by neuronal activity can alter synaptic plasticity, which constitutes part of the mechanisms of learning and memory. In the latter half of the chapter, we describe the role of epigenetic plasticity in non-dividing neurons. We also discuss the robust identity of the neuronal cell fate, as exemplified by the extremely poor ability of neurons to be reprogrammed to pluripotent stem cells.",
author = "Naoki Yamamoto and Masahiro Uesaka and Takuya Imamura and Kinichi Nakashima",
year = "2014",
month = "6",
day = "20",
doi = "10.1016/B978-0-12-417114-5.00004-8",
language = "English",
isbn = "9780124171145",
pages = "51--78",
booktitle = "Epigenetics in Psychiatry",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Roles of Epigenetics in the Neural Stem Cell and Neuron

AU - Yamamoto, Naoki

AU - Uesaka, Masahiro

AU - Imamura, Takuya

AU - Nakashima, Kinichi

PY - 2014/6/20

Y1 - 2014/6/20

N2 - For higher-order functions of the mammalian brain such as the regulation of motor behavior, consciousness, emotion, learning, and memory, neurons have to establish complicated and elaborate networks. In addition, the functions of neurons are critically supported by glial cells (astrocytes and oligodendrocytes). All of these neural cell types (i.e., neurons, astrocytes, and oligodendrocytes) are generated from common neural stem cells (NSCs), which also have self-renewal activity. Accumulating evidence suggests that the behavior of NSCs is influenced spatiotemporally by both cell-extrinsic factors, including cytokine signaling, and cell-intrinsic epigenetic changes, which together regulate the proliferation and fate decisions of NSCs to produce glial cells or neurons, including different neuronal subtypes, in a spatiotemporal manner. In the first half of this chapter, we summarize recent advances in elucidating the role of epigenetic control in the differentiation of NSCs. In postmitotic neurons, as well as NSCs, several orchestrated epigenetic mechanisms underlie neuronal functioning critical for memory formation. Recent studies have revealed the presence and physiological significance of changes of the epigenetic modifications within a neuron of an already defined cell fate. A dynamic change of epigenetic status induced by neuronal activity can alter synaptic plasticity, which constitutes part of the mechanisms of learning and memory. In the latter half of the chapter, we describe the role of epigenetic plasticity in non-dividing neurons. We also discuss the robust identity of the neuronal cell fate, as exemplified by the extremely poor ability of neurons to be reprogrammed to pluripotent stem cells.

AB - For higher-order functions of the mammalian brain such as the regulation of motor behavior, consciousness, emotion, learning, and memory, neurons have to establish complicated and elaborate networks. In addition, the functions of neurons are critically supported by glial cells (astrocytes and oligodendrocytes). All of these neural cell types (i.e., neurons, astrocytes, and oligodendrocytes) are generated from common neural stem cells (NSCs), which also have self-renewal activity. Accumulating evidence suggests that the behavior of NSCs is influenced spatiotemporally by both cell-extrinsic factors, including cytokine signaling, and cell-intrinsic epigenetic changes, which together regulate the proliferation and fate decisions of NSCs to produce glial cells or neurons, including different neuronal subtypes, in a spatiotemporal manner. In the first half of this chapter, we summarize recent advances in elucidating the role of epigenetic control in the differentiation of NSCs. In postmitotic neurons, as well as NSCs, several orchestrated epigenetic mechanisms underlie neuronal functioning critical for memory formation. Recent studies have revealed the presence and physiological significance of changes of the epigenetic modifications within a neuron of an already defined cell fate. A dynamic change of epigenetic status induced by neuronal activity can alter synaptic plasticity, which constitutes part of the mechanisms of learning and memory. In the latter half of the chapter, we describe the role of epigenetic plasticity in non-dividing neurons. We also discuss the robust identity of the neuronal cell fate, as exemplified by the extremely poor ability of neurons to be reprogrammed to pluripotent stem cells.

UR - http://www.scopus.com/inward/record.url?scp=84942936562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942936562&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-417114-5.00004-8

DO - 10.1016/B978-0-12-417114-5.00004-8

M3 - Chapter

AN - SCOPUS:84942936562

SN - 9780124171145

SP - 51

EP - 78

BT - Epigenetics in Psychiatry

PB - Elsevier Inc.

ER -