Roles of odorant receptors in projecting axons in the mouse olfactory system

Takeshi Imai, Hitoshi Sakano

研究成果: ジャーナルへの寄稿評論記事

34 引用 (Scopus)

抄録

In the mouse olfactory epithelium, there are about ten million olfactory sensory neurons, each expressing a single type of odorant receptor out of ∼1000. Olfactory sensory neurons expressing the same odorant receptor converge their axons to a specific set of glomeruli on the olfactory bulb. How odorant receptors play an instructive role in the projection of axons to the olfactory bulb has been one of the major issues of developmental neurobiology. Recent studies revealed previously overlooked roles of odorant receptor-derived cAMP signals in the axonal projection of olfactory sensory neurons; the levels of cAMP and neuronal activity appear to determine the expression levels of axon guidance/sorting molecules and thereby direct the axonal projection of olfactory sensory neurons. These findings provide new insights as to how peripheral inputs instruct neuronal circuit formation in the mammalian brain.

元の言語英語
ページ(範囲)507-515
ページ数9
ジャーナルCurrent Opinion in Neurobiology
17
発行部数5
DOI
出版物ステータス出版済み - 10 1 2007

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Odorant Receptors
Olfactory Receptor Neurons
Axons
Olfactory Bulb
Olfactory Mucosa
Neurobiology
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Roles of odorant receptors in projecting axons in the mouse olfactory system. / Imai, Takeshi; Sakano, Hitoshi.

:: Current Opinion in Neurobiology, 巻 17, 番号 5, 01.10.2007, p. 507-515.

研究成果: ジャーナルへの寄稿評論記事

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