Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection

Yasunobu Yoshikai

    研究成果: ジャーナルへの寄稿評論記事

    44 引用 (Scopus)

    抄録

    Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. At physiological concentrations, vasodilator prostaglandins enhance the vascular permeability effects of histamine and bradykinin, and leukotrienes are important mediators of leukocyte accumulation during acute inflammation. On the other hand, prostaglandin metabolites such as cyclopentenone prostaglandins contribute to the resolution of acute inflammation through inhibition of nuclear factor-κB activation. Thus, arachidonic acid oxygenation products mediate diverse effects that induce and resolve acute inflammation caused by bacterial infection.

    元の言語英語
    ページ(範囲)257-263
    ページ数7
    ジャーナルCurrent Opinion in Infectious Diseases
    14
    発行部数3
    DOI
    出版物ステータス出版済み - 1 1 2001

    Fingerprint

    Leukotrienes
    Bacterial Infections
    Prostaglandins
    Inflammation
    Arachidonate 5-Lipoxygenase
    Phospholipases A2
    Thromboxanes
    Capillary Permeability
    Bradykinin
    Prostaglandin-Endoperoxide Synthases
    Vasodilator Agents
    Arachidonic Acid
    Histamine
    Leukocytes

    All Science Journal Classification (ASJC) codes

    • Microbiology (medical)
    • Infectious Diseases

    これを引用

    Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection. / Yoshikai, Yasunobu.

    :: Current Opinion in Infectious Diseases, 巻 14, 番号 3, 01.01.2001, p. 257-263.

    研究成果: ジャーナルへの寄稿評論記事

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    abstract = "Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. At physiological concentrations, vasodilator prostaglandins enhance the vascular permeability effects of histamine and bradykinin, and leukotrienes are important mediators of leukocyte accumulation during acute inflammation. On the other hand, prostaglandin metabolites such as cyclopentenone prostaglandins contribute to the resolution of acute inflammation through inhibition of nuclear factor-κB activation. Thus, arachidonic acid oxygenation products mediate diverse effects that induce and resolve acute inflammation caused by bacterial infection.",
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    AB - Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. At physiological concentrations, vasodilator prostaglandins enhance the vascular permeability effects of histamine and bradykinin, and leukotrienes are important mediators of leukocyte accumulation during acute inflammation. On the other hand, prostaglandin metabolites such as cyclopentenone prostaglandins contribute to the resolution of acute inflammation through inhibition of nuclear factor-κB activation. Thus, arachidonic acid oxygenation products mediate diverse effects that induce and resolve acute inflammation caused by bacterial infection.

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