Roles of ubiquitin in autophagy and cell death

Carlos Gómez-Díaz, Fumiyo Ikeda

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.

元の言語英語
ページ(範囲)125-135
ページ数11
ジャーナルSeminars in Cell and Developmental Biology
93
DOI
出版物ステータス出版済み - 9 2019
外部発表Yes

Fingerprint

Autophagy
Ubiquitin
Cell Death
Cell Survival
Garbage
Recycling
Post Translational Protein Processing
Apoptosis
Pathology
Inflammation
Food
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

これを引用

Roles of ubiquitin in autophagy and cell death. / Gómez-Díaz, Carlos; Ikeda, Fumiyo.

:: Seminars in Cell and Developmental Biology, 巻 93, 09.2019, p. 125-135.

研究成果: ジャーナルへの寄稿評論記事

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