Ruthenium-catalyzed asymmetric hydrogenation of N-Boc-indoles

Ryoichi Kuwano, Manabu Kashiwabara

研究成果: ジャーナルへの寄稿記事

147 引用 (Scopus)

抄録

Highly enantioselective hydrogenation of various N-Boc-indoles proceeded successfully in the presence of the ruthenium complex generated from an appropriate ruthenium precursor and a trans-chelate chiral bisphosphine PhTRAP. Various 2- or 3-substituted indoles were converted into chiral indolines with high enantiomeric excesses (up to 95% ee). The PhTRAP-ruthenium catalyst was able to promote the hydrogenation of 2,3-dimethylindoles, giving cis-2,3-dimethylindolines with 72% ee.

元の言語英語
ページ(範囲)2653-2655
ページ数3
ジャーナルOrganic Letters
8
発行部数12
DOI
出版物ステータス出版済み - 6 8 2006

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Indoles
Hydrogenation
Ruthenium
indoles
ruthenium
hydrogenation
chelates
catalysts
Catalysts

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

これを引用

Ruthenium-catalyzed asymmetric hydrogenation of N-Boc-indoles. / Kuwano, Ryoichi; Kashiwabara, Manabu.

:: Organic Letters, 巻 8, 番号 12, 08.06.2006, p. 2653-2655.

研究成果: ジャーナルへの寄稿記事

Kuwano, Ryoichi ; Kashiwabara, Manabu. / Ruthenium-catalyzed asymmetric hydrogenation of N-Boc-indoles. :: Organic Letters. 2006 ; 巻 8, 番号 12. pp. 2653-2655.
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