S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches

Kazufumi Kunimura, Daiji Sakata, Xin Tun, Takehito Uruno, Miho Ushijima, Tomoya Katakai, Akira Shiraishi, Ryosuke Aihara, Yasuhisa Kamikaseda, Keisuke Matsubara, Hirokazu Kanegane, Shinichiro Sawa, Gérard Eberl, Shouichi Ohga, Yasunobu Yoshikai, Yoshinori Fukui

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Intestinal microfold cells (M cells) in Peyer's patches are a special subset of epithelial cells that initiate mucosal immune responses through uptake of luminal antigens. Although the cytokine receptor activator of nuclear factor-κB ligand (RANKL) expressed on mesenchymal cells triggers differentiation into M cells, other environmental cues remain unknown. Here, we show that the metastasis-promoting protein S100A4 is required for development of mature M cells. S100A4-producing cells are a heterogenous cell population including lysozyme-expressing dendritic cells and group 3 innate lymphoid cells. We found that in the absence of DOCK8, a Cdc42 activator critical for interstitial leukocyte migration, S100A4-producing cells are reduced in the subepithelial dome, resulting in a maturation defect of M cells. While S100A4 promotes differentiation into mature M cells in organoid culture, genetic inactivation of S100a4 prevents the development of mature M cells in mice. Thus, S100A4 is a key environmental cue that regulates M cell differentiation in collaboration with RANKL.

元の言語英語
ページ(範囲)2823-2834.e7
ジャーナルCell Reports
29
発行部数9
DOI
出版物ステータス出版済み - 11 26 2019

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Peyer's Patches
Cytokine Receptors
Domes
Muramidase
Cells
Ligands
Antigens
Defects
Proteins
Cues
Cell Differentiation
Organoids
Epithelial Cells
Dendritic Cells
S100 Calcium-Binding Protein A4
Mucosal Immunity
Leukocytes
Lymphocytes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches. / Kunimura, Kazufumi; Sakata, Daiji; Tun, Xin; Uruno, Takehito; Ushijima, Miho; Katakai, Tomoya; Shiraishi, Akira; Aihara, Ryosuke; Kamikaseda, Yasuhisa; Matsubara, Keisuke; Kanegane, Hirokazu; Sawa, Shinichiro; Eberl, Gérard; Ohga, Shouichi; Yoshikai, Yasunobu; Fukui, Yoshinori.

:: Cell Reports, 巻 29, 番号 9, 26.11.2019, p. 2823-2834.e7.

研究成果: ジャーナルへの寄稿記事

Kunimura, K, Sakata, D, Tun, X, Uruno, T, Ushijima, M, Katakai, T, Shiraishi, A, Aihara, R, Kamikaseda, Y, Matsubara, K, Kanegane, H, Sawa, S, Eberl, G, Ohga, S, Yoshikai, Y & Fukui, Y 2019, 'S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches', Cell Reports, 巻. 29, 番号 9, pp. 2823-2834.e7. https://doi.org/10.1016/j.celrep.2019.10.091
Kunimura, Kazufumi ; Sakata, Daiji ; Tun, Xin ; Uruno, Takehito ; Ushijima, Miho ; Katakai, Tomoya ; Shiraishi, Akira ; Aihara, Ryosuke ; Kamikaseda, Yasuhisa ; Matsubara, Keisuke ; Kanegane, Hirokazu ; Sawa, Shinichiro ; Eberl, Gérard ; Ohga, Shouichi ; Yoshikai, Yasunobu ; Fukui, Yoshinori. / S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches. :: Cell Reports. 2019 ; 巻 29, 番号 9. pp. 2823-2834.e7.
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AU - Ushijima, Miho

AU - Katakai, Tomoya

AU - Shiraishi, Akira

AU - Aihara, Ryosuke

AU - Kamikaseda, Yasuhisa

AU - Matsubara, Keisuke

AU - Kanegane, Hirokazu

AU - Sawa, Shinichiro

AU - Eberl, Gérard

AU - Ohga, Shouichi

AU - Yoshikai, Yasunobu

AU - Fukui, Yoshinori

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