S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma

Taketo Matsunaga, Ohtsuka Takao, Koichi Asano, Hideyo Kimura, Kenoki Ouchida, Hidehisa Kitada, Noboru Ideno, Yasuhisa Mori, Shoji Tokunaga, Yoshinao Oda, Sushovan Guha, Massimo Raimondo, Masafumi Nakamura, Masao Tanaka

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Objectives The development of an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is of paramount importance. This study assessed the diagnostic utility in pancreatic diseases of duodenal markers during upper gastrointestinal endoscopy (GIE) or endoscopic ultrasonography. Methods This study prospectively enrolled 299 consecutive participants, including 94 patients with PDACs, 144 patients with other pancreatic diseases, and 61 normal individuals as control subjects. All subjects underwent upper GIE or endoscopic ultrasonography either at Kyushu University Hospital (Fukuoka, Japan) or the Mayo Clinic (Jacksonville, Fla) from October 2011 to July 2014. Duodenal fluid (DF) was collected without secretin stimulation and of carcinoembryonic antigen and S100 calcium-binding protein P (S100P) concentrations were measured. Results Concentrations of S100P in DF were significantly higher in patients with PDAC and chronic pancreatitis than in control subjects (P < 0.01). A logistic regression model that included age found that the sensitivity and specificity of S100P concentration in diagnosing stages 0/IA/IB/IIA PDAC were 85% and 77%, respectively, with an area under the receiver operating characteristic curve of 0.82. Carcinoembryonic antigen concentrations in DF of patients with pancreatic disease did not differ significantly from control subjects. Conclusions Analysis of S100P concentration in DF, in combination with routine screening upper GIE, may facilitate the detection of PDAC.

元の言語英語
ページ(範囲)1288-1295
ページ数8
ジャーナルPancreas
46
発行部数10
DOI
出版物ステータス出版済み - 11 1 2017

Fingerprint

Pancreatic Diseases
Gastrointestinal Endoscopy
Adenocarcinoma
Endosonography
Carcinoembryonic Antigen
Logistic Models
Calcium-Binding Proteins
Secretin
Chronic Pancreatitis
ROC Curve
Japan
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

これを引用

S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma. / Matsunaga, Taketo; Takao, Ohtsuka; Asano, Koichi; Kimura, Hideyo; Ouchida, Kenoki; Kitada, Hidehisa; Ideno, Noboru; Mori, Yasuhisa; Tokunaga, Shoji; Oda, Yoshinao; Guha, Sushovan; Raimondo, Massimo; Nakamura, Masafumi; Tanaka, Masao.

:: Pancreas, 巻 46, 番号 10, 01.11.2017, p. 1288-1295.

研究成果: ジャーナルへの寄稿記事

Matsunaga, T, Takao, O, Asano, K, Kimura, H, Ouchida, K, Kitada, H, Ideno, N, Mori, Y, Tokunaga, S, Oda, Y, Guha, S, Raimondo, M, Nakamura, M & Tanaka, M 2017, 'S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma', Pancreas, 巻. 46, 番号 10, pp. 1288-1295. https://doi.org/10.1097/MPA.0000000000000940
Matsunaga, Taketo ; Takao, Ohtsuka ; Asano, Koichi ; Kimura, Hideyo ; Ouchida, Kenoki ; Kitada, Hidehisa ; Ideno, Noboru ; Mori, Yasuhisa ; Tokunaga, Shoji ; Oda, Yoshinao ; Guha, Sushovan ; Raimondo, Massimo ; Nakamura, Masafumi ; Tanaka, Masao. / S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma. :: Pancreas. 2017 ; 巻 46, 番号 10. pp. 1288-1295.
@article{0b14f12447b842f9b0f5dca1064440aa,
title = "S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma",
abstract = "Objectives The development of an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is of paramount importance. This study assessed the diagnostic utility in pancreatic diseases of duodenal markers during upper gastrointestinal endoscopy (GIE) or endoscopic ultrasonography. Methods This study prospectively enrolled 299 consecutive participants, including 94 patients with PDACs, 144 patients with other pancreatic diseases, and 61 normal individuals as control subjects. All subjects underwent upper GIE or endoscopic ultrasonography either at Kyushu University Hospital (Fukuoka, Japan) or the Mayo Clinic (Jacksonville, Fla) from October 2011 to July 2014. Duodenal fluid (DF) was collected without secretin stimulation and of carcinoembryonic antigen and S100 calcium-binding protein P (S100P) concentrations were measured. Results Concentrations of S100P in DF were significantly higher in patients with PDAC and chronic pancreatitis than in control subjects (P < 0.01). A logistic regression model that included age found that the sensitivity and specificity of S100P concentration in diagnosing stages 0/IA/IB/IIA PDAC were 85{\%} and 77{\%}, respectively, with an area under the receiver operating characteristic curve of 0.82. Carcinoembryonic antigen concentrations in DF of patients with pancreatic disease did not differ significantly from control subjects. Conclusions Analysis of S100P concentration in DF, in combination with routine screening upper GIE, may facilitate the detection of PDAC.",
author = "Taketo Matsunaga and Ohtsuka Takao and Koichi Asano and Hideyo Kimura and Kenoki Ouchida and Hidehisa Kitada and Noboru Ideno and Yasuhisa Mori and Shoji Tokunaga and Yoshinao Oda and Sushovan Guha and Massimo Raimondo and Masafumi Nakamura and Masao Tanaka",
year = "2017",
month = "11",
day = "1",
doi = "10.1097/MPA.0000000000000940",
language = "English",
volume = "46",
pages = "1288--1295",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - S100P in Duodenal Fluid Is a Useful Diagnostic Marker for Pancreatic Ductal Adenocarcinoma

AU - Matsunaga, Taketo

AU - Takao, Ohtsuka

AU - Asano, Koichi

AU - Kimura, Hideyo

AU - Ouchida, Kenoki

AU - Kitada, Hidehisa

AU - Ideno, Noboru

AU - Mori, Yasuhisa

AU - Tokunaga, Shoji

AU - Oda, Yoshinao

AU - Guha, Sushovan

AU - Raimondo, Massimo

AU - Nakamura, Masafumi

AU - Tanaka, Masao

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objectives The development of an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is of paramount importance. This study assessed the diagnostic utility in pancreatic diseases of duodenal markers during upper gastrointestinal endoscopy (GIE) or endoscopic ultrasonography. Methods This study prospectively enrolled 299 consecutive participants, including 94 patients with PDACs, 144 patients with other pancreatic diseases, and 61 normal individuals as control subjects. All subjects underwent upper GIE or endoscopic ultrasonography either at Kyushu University Hospital (Fukuoka, Japan) or the Mayo Clinic (Jacksonville, Fla) from October 2011 to July 2014. Duodenal fluid (DF) was collected without secretin stimulation and of carcinoembryonic antigen and S100 calcium-binding protein P (S100P) concentrations were measured. Results Concentrations of S100P in DF were significantly higher in patients with PDAC and chronic pancreatitis than in control subjects (P < 0.01). A logistic regression model that included age found that the sensitivity and specificity of S100P concentration in diagnosing stages 0/IA/IB/IIA PDAC were 85% and 77%, respectively, with an area under the receiver operating characteristic curve of 0.82. Carcinoembryonic antigen concentrations in DF of patients with pancreatic disease did not differ significantly from control subjects. Conclusions Analysis of S100P concentration in DF, in combination with routine screening upper GIE, may facilitate the detection of PDAC.

AB - Objectives The development of an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is of paramount importance. This study assessed the diagnostic utility in pancreatic diseases of duodenal markers during upper gastrointestinal endoscopy (GIE) or endoscopic ultrasonography. Methods This study prospectively enrolled 299 consecutive participants, including 94 patients with PDACs, 144 patients with other pancreatic diseases, and 61 normal individuals as control subjects. All subjects underwent upper GIE or endoscopic ultrasonography either at Kyushu University Hospital (Fukuoka, Japan) or the Mayo Clinic (Jacksonville, Fla) from October 2011 to July 2014. Duodenal fluid (DF) was collected without secretin stimulation and of carcinoembryonic antigen and S100 calcium-binding protein P (S100P) concentrations were measured. Results Concentrations of S100P in DF were significantly higher in patients with PDAC and chronic pancreatitis than in control subjects (P < 0.01). A logistic regression model that included age found that the sensitivity and specificity of S100P concentration in diagnosing stages 0/IA/IB/IIA PDAC were 85% and 77%, respectively, with an area under the receiver operating characteristic curve of 0.82. Carcinoembryonic antigen concentrations in DF of patients with pancreatic disease did not differ significantly from control subjects. Conclusions Analysis of S100P concentration in DF, in combination with routine screening upper GIE, may facilitate the detection of PDAC.

UR - http://www.scopus.com/inward/record.url?scp=85032187931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032187931&partnerID=8YFLogxK

U2 - 10.1097/MPA.0000000000000940

DO - 10.1097/MPA.0000000000000940

M3 - Article

VL - 46

SP - 1288

EP - 1295

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 10

ER -