Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu, Shinichi Nishimura, Go Hirai, Masashi Ito, Teppei Kawahara, Miho Izumikawa, Mikiko Sodeoka, Kazuo Shin-Ya, Toshio Tsuchida, Hideaki Kakeya

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

本文言語英語
ページ(範囲)8074-8077
ページ数4
ジャーナルChemical Communications
51
38
DOI
出版ステータス出版済み - 5 11 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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