Safety margins of hepatocellular carcinoma demonstrated by 3-dimensional fused images of computed tomographic hepatic arteriography/unenhanced computed tomography: Prognostic significance in patients who underwent transcatheter arterial chemoembolization

Tsuyoshi Tajima, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Kakihara, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

To investigate the relation between safety margins (SMs) and treatment efficacy for hepatocellular carcinoma (HCC) by transcatheter arterial chemoembolization (TACE) using 3-dimensional fusion images of computed tomographic (CT) hepatic arteriography and unenhanced CT. Methods: Fifty-three patients with HCC who underwent subsegmental/segmental TACE were followed up. Lipiodol accumulation patterns within the lesion were classified as determined by unenhanced CT immediately after TACE. Lipiodol accumulation patterns around the lesion were classified as determined by 3-dimensional fusion images with special reference to the SMs, which were compared with the local recurrence (LR) rates. Results: Local recurrence was detected in 29 patients (55%) during the follow-up period. When an SM less than 3 mm was defined as insufficient, the LR rates in groups with and without sufficient SMs were 33% (9/25) and 71% (20/28), respectively (P = 0.0136). In 38 nodules with complete Lipiodol accumulation, 10 (63%) of 16 nodules with LR showed the narrow SM (<3 mm), whereas 5 (23%) of 22 nodules without LR showed the narrow SM (P = 0.1341). Multivariate analyses showed that complete Lipiodol accumulation seemed to be an independent prognostic factor (P = 0.0288). Conclusions: 3-Dimensional fusion image was suggested to be valuable for the early detection of viable components within the HCC with insufficient SMs after TACE.

元の言語英語
ページ(範囲)712-719
ページ数8
ジャーナルJournal of Computer Assisted Tomography
34
発行部数5
DOI
出版物ステータス出版済み - 9 1 2010

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Hepatocellular Carcinoma
Angiography
Ethiodized Oil
Tomography
Safety
Liver
Recurrence
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

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title = "Safety margins of hepatocellular carcinoma demonstrated by 3-dimensional fused images of computed tomographic hepatic arteriography/unenhanced computed tomography: Prognostic significance in patients who underwent transcatheter arterial chemoembolization",
abstract = "To investigate the relation between safety margins (SMs) and treatment efficacy for hepatocellular carcinoma (HCC) by transcatheter arterial chemoembolization (TACE) using 3-dimensional fusion images of computed tomographic (CT) hepatic arteriography and unenhanced CT. Methods: Fifty-three patients with HCC who underwent subsegmental/segmental TACE were followed up. Lipiodol accumulation patterns within the lesion were classified as determined by unenhanced CT immediately after TACE. Lipiodol accumulation patterns around the lesion were classified as determined by 3-dimensional fusion images with special reference to the SMs, which were compared with the local recurrence (LR) rates. Results: Local recurrence was detected in 29 patients (55{\%}) during the follow-up period. When an SM less than 3 mm was defined as insufficient, the LR rates in groups with and without sufficient SMs were 33{\%} (9/25) and 71{\%} (20/28), respectively (P = 0.0136). In 38 nodules with complete Lipiodol accumulation, 10 (63{\%}) of 16 nodules with LR showed the narrow SM (<3 mm), whereas 5 (23{\%}) of 22 nodules without LR showed the narrow SM (P = 0.1341). Multivariate analyses showed that complete Lipiodol accumulation seemed to be an independent prognostic factor (P = 0.0288). Conclusions: 3-Dimensional fusion image was suggested to be valuable for the early detection of viable components within the HCC with insufficient SMs after TACE.",
author = "Tsuyoshi Tajima and Akihiro Nishie and Yoshiki Asayama and Kousei Ishigami and Yasuhiro Ushijima and Daisuke Kakihara and Hiroshi Honda",
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T1 - Safety margins of hepatocellular carcinoma demonstrated by 3-dimensional fused images of computed tomographic hepatic arteriography/unenhanced computed tomography

T2 - Prognostic significance in patients who underwent transcatheter arterial chemoembolization

AU - Tajima, Tsuyoshi

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Ishigami, Kousei

AU - Ushijima, Yasuhiro

AU - Kakihara, Daisuke

AU - Honda, Hiroshi

PY - 2010/9/1

Y1 - 2010/9/1

N2 - To investigate the relation between safety margins (SMs) and treatment efficacy for hepatocellular carcinoma (HCC) by transcatheter arterial chemoembolization (TACE) using 3-dimensional fusion images of computed tomographic (CT) hepatic arteriography and unenhanced CT. Methods: Fifty-three patients with HCC who underwent subsegmental/segmental TACE were followed up. Lipiodol accumulation patterns within the lesion were classified as determined by unenhanced CT immediately after TACE. Lipiodol accumulation patterns around the lesion were classified as determined by 3-dimensional fusion images with special reference to the SMs, which were compared with the local recurrence (LR) rates. Results: Local recurrence was detected in 29 patients (55%) during the follow-up period. When an SM less than 3 mm was defined as insufficient, the LR rates in groups with and without sufficient SMs were 33% (9/25) and 71% (20/28), respectively (P = 0.0136). In 38 nodules with complete Lipiodol accumulation, 10 (63%) of 16 nodules with LR showed the narrow SM (<3 mm), whereas 5 (23%) of 22 nodules without LR showed the narrow SM (P = 0.1341). Multivariate analyses showed that complete Lipiodol accumulation seemed to be an independent prognostic factor (P = 0.0288). Conclusions: 3-Dimensional fusion image was suggested to be valuable for the early detection of viable components within the HCC with insufficient SMs after TACE.

AB - To investigate the relation between safety margins (SMs) and treatment efficacy for hepatocellular carcinoma (HCC) by transcatheter arterial chemoembolization (TACE) using 3-dimensional fusion images of computed tomographic (CT) hepatic arteriography and unenhanced CT. Methods: Fifty-three patients with HCC who underwent subsegmental/segmental TACE were followed up. Lipiodol accumulation patterns within the lesion were classified as determined by unenhanced CT immediately after TACE. Lipiodol accumulation patterns around the lesion were classified as determined by 3-dimensional fusion images with special reference to the SMs, which were compared with the local recurrence (LR) rates. Results: Local recurrence was detected in 29 patients (55%) during the follow-up period. When an SM less than 3 mm was defined as insufficient, the LR rates in groups with and without sufficient SMs were 33% (9/25) and 71% (20/28), respectively (P = 0.0136). In 38 nodules with complete Lipiodol accumulation, 10 (63%) of 16 nodules with LR showed the narrow SM (<3 mm), whereas 5 (23%) of 22 nodules without LR showed the narrow SM (P = 0.1341). Multivariate analyses showed that complete Lipiodol accumulation seemed to be an independent prognostic factor (P = 0.0288). Conclusions: 3-Dimensional fusion image was suggested to be valuable for the early detection of viable components within the HCC with insufficient SMs after TACE.

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