Saliva as a potential tool for diagnosis of dry mouth including Sjögren's syndrome

Keiko Oyama, Masafumi Moriyama, Hayashida Jun-Nosuke, A. Tanaka, takashi maehara, S. Ieda, S. Furukawa, M. Ohta, Y. Imabayashi, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

抄録

Objectives: Recently, the use of saliva as a diagnostic tool has gained considerable attention because it is non-invasive and easy to perform repeatedly. In this study, we focused on soluble molecules in saliva to establish a new diagnostic method for xerostomia. Materials and Methods: Saliva was obtained from 90 patients with Sjögren's syndrome (SS), 22 patients with xerostomia associated with neurogenic/neuropsychiatric disorders and drugs (XND), 30 patients with radiation-induced xerostomia (RX), and 36 healthy controls. Concentrations of helper T (Th) cytokines in saliva were measured by flow cytometric analysis. Concentrations of secretory IgA (SIgA) and chromogranin A (CgA) were measured by ELISA. Results: Unstimulated and stimulated whole saliva from patients with SS, XND, and RX was significantly reduced compared with controls. Th1 and Th2 cytokines from SS patients were significantly higher than controls. Furthermore, Th2 cytokines were closely associated with strong lymphocytic accumulation in salivary glands from SS patients, while Th1 and Th17 cytokines were negatively associated. SIgA levels were not significantly different between all patient groups and controls. CgA levels from XND patients were significantly higher than controls. Conclusions: The measurement of cytokines, CgA, and SIgA in saliva is suggested to be useful for the diagnosis of xerostomia and also to reveal disease status.

元の言語英語
ページ(範囲)224-231
ページ数8
ジャーナルOral Diseases
21
発行部数2
DOI
出版物ステータス出版済み - 1 1 2015

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Saliva
Mouth
Xerostomia
Chromogranin A
Secretory Immunoglobulin A
Cytokines
Radiation Injuries
Salivary Glands
Enzyme-Linked Immunosorbent Assay
Radiation
Control Groups
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

これを引用

Saliva as a potential tool for diagnosis of dry mouth including Sjögren's syndrome. / Oyama, Keiko; Moriyama, Masafumi; Jun-Nosuke, Hayashida; Tanaka, A.; maehara, takashi; Ieda, S.; Furukawa, S.; Ohta, M.; Imabayashi, Y.; Nakamura, Seiji.

:: Oral Diseases, 巻 21, 番号 2, 01.01.2015, p. 224-231.

研究成果: ジャーナルへの寄稿記事

Oyama, K, Moriyama, M, Jun-Nosuke, H, Tanaka, A, maehara, T, Ieda, S, Furukawa, S, Ohta, M, Imabayashi, Y & Nakamura, S 2015, 'Saliva as a potential tool for diagnosis of dry mouth including Sjögren's syndrome', Oral Diseases, 巻. 21, 番号 2, pp. 224-231. https://doi.org/10.1111/odi.12252
Oyama, Keiko ; Moriyama, Masafumi ; Jun-Nosuke, Hayashida ; Tanaka, A. ; maehara, takashi ; Ieda, S. ; Furukawa, S. ; Ohta, M. ; Imabayashi, Y. ; Nakamura, Seiji. / Saliva as a potential tool for diagnosis of dry mouth including Sjögren's syndrome. :: Oral Diseases. 2015 ; 巻 21, 番号 2. pp. 224-231.
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AU - Oyama, Keiko

AU - Moriyama, Masafumi

AU - Jun-Nosuke, Hayashida

AU - Tanaka, A.

AU - maehara, takashi

AU - Ieda, S.

AU - Furukawa, S.

AU - Ohta, M.

AU - Imabayashi, Y.

AU - Nakamura, Seiji

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