Sarcopenia is an independent predictor of complications after colorectal cancer surgery

Ryota Nakanishi, Eiji Oki, Shun Sasaki, Kosuke Hirose, Tomoko Jogo, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudo, Junji Kurashige, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Hiroshi Saeki, Yoshihiko Maehara

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Purpose: The significance of sarcopenia after colorectal cancer (CRC) resection has only been discussed with relatively small samples or short follow-up periods. This study aimed to clarify the clinical significance of sarcopenia in a large-sample study. Methods: We retrospectively analyzed the relationship between sarcopenia and clinical factors, surgical outcomes, and the survival in 494 patients who underwent CRC surgery between 2004 and 2013. Sarcopenia was defined based on the sex-specific skeletal muscle mass index measured by preoperative computed tomography. Results: Sarcopenia was associated with sex (higher rate of male, P < 0.0001), and low body mass index (P < 0.0001), but not age or tumor stage. Sarcopenia was associated with higher incidence of all postoperative complications (P = 0.02), especially for patients with Clavien–Dindo classification grade ≥2 (CDC; P = 0.0007). Postoperative hospital stays were significantly longer for sarcopenic patients than for non-sarcopenic patients (P = 0.02). In a multivariate analysis, sarcopenia was an independent predictor for postoperative complications (P = 0.01, odds ratio 1.82, 95% confidence interval 1.13–3.00). Among postoperative complications (CDC grade ≥2), sarcopenia was correlated with non-surgical-site infections (P = 0.03). Sarcopenia was not correlated with the overall or recurrence-free survival. Conclusions: Sarcopenia was an independent predictive factor for postoperative complications after CRC surgery.

元の言語英語
ページ(範囲)151-157
ページ数7
ジャーナルSurgery today
48
発行部数2
DOI
出版物ステータス出版済み - 2 1 2018

All Science Journal Classification (ASJC) codes

  • Surgery

フィンガープリント Sarcopenia is an independent predictor of complications after colorectal cancer surgery' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Nakanishi, R., Oki, E., Sasaki, S., Hirose, K., Jogo, T., Edahiro, K., Korehisa, S., Taniguchi, D., Kudo, K., Kurashige, J., Sugiyama, M., Nakashima, Y., Ohgaki, K., Saeki, H., & Maehara, Y. (2018). Sarcopenia is an independent predictor of complications after colorectal cancer surgery. Surgery today, 48(2), 151-157. https://doi.org/10.1007/s00595-017-1564-0