Sarcopenia is an independent predictor of complications after colorectal cancer surgery

Ryota Nakanishi, Eiji Oki, Shun Sasaki, Kosuke Hirose, Tomoko Jogo, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudo, Junji Kurashige, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Hiroshi Saeki, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Purpose: The significance of sarcopenia after colorectal cancer (CRC) resection has only been discussed with relatively small samples or short follow-up periods. This study aimed to clarify the clinical significance of sarcopenia in a large-sample study. Methods: We retrospectively analyzed the relationship between sarcopenia and clinical factors, surgical outcomes, and the survival in 494 patients who underwent CRC surgery between 2004 and 2013. Sarcopenia was defined based on the sex-specific skeletal muscle mass index measured by preoperative computed tomography. Results: Sarcopenia was associated with sex (higher rate of male, P < 0.0001), and low body mass index (P < 0.0001), but not age or tumor stage. Sarcopenia was associated with higher incidence of all postoperative complications (P = 0.02), especially for patients with Clavien–Dindo classification grade ≥2 (CDC; P = 0.0007). Postoperative hospital stays were significantly longer for sarcopenic patients than for non-sarcopenic patients (P = 0.02). In a multivariate analysis, sarcopenia was an independent predictor for postoperative complications (P = 0.01, odds ratio 1.82, 95% confidence interval 1.13–3.00). Among postoperative complications (CDC grade ≥2), sarcopenia was correlated with non-surgical-site infections (P = 0.03). Sarcopenia was not correlated with the overall or recurrence-free survival. Conclusions: Sarcopenia was an independent predictive factor for postoperative complications after CRC surgery.

元の言語英語
ページ(範囲)151-157
ページ数7
ジャーナルSurgery today
48
発行部数2
DOI
出版物ステータス出版済み - 2 1 2018

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Sarcopenia
Colorectal Surgery
Colorectal Neoplasms
Centers for Disease Control and Prevention (U.S.)
Survival
Length of Stay
Skeletal Muscle
Body Mass Index
Multivariate Analysis
Odds Ratio
Tomography
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Nakanishi, R., Oki, E., Sasaki, S., Hirose, K., Jogo, T., Edahiro, K., ... Maehara, Y. (2018). Sarcopenia is an independent predictor of complications after colorectal cancer surgery. Surgery today, 48(2), 151-157. https://doi.org/10.1007/s00595-017-1564-0

Sarcopenia is an independent predictor of complications after colorectal cancer surgery. / Nakanishi, Ryota; Oki, Eiji; Sasaki, Shun; Hirose, Kosuke; Jogo, Tomoko; Edahiro, Keitaro; Korehisa, Shotaro; Taniguchi, Daisuke; Kudo, Kensuke; Kurashige, Junji; Sugiyama, Masahiko; Nakashima, Yuichiro; Ohgaki, Kippei; Saeki, Hiroshi; Maehara, Yoshihiko.

:: Surgery today, 巻 48, 番号 2, 01.02.2018, p. 151-157.

研究成果: ジャーナルへの寄稿記事

Nakanishi, R, Oki, E, Sasaki, S, Hirose, K, Jogo, T, Edahiro, K, Korehisa, S, Taniguchi, D, Kudo, K, Kurashige, J, Sugiyama, M, Nakashima, Y, Ohgaki, K, Saeki, H & Maehara, Y 2018, 'Sarcopenia is an independent predictor of complications after colorectal cancer surgery', Surgery today, 巻. 48, 番号 2, pp. 151-157. https://doi.org/10.1007/s00595-017-1564-0
Nakanishi, Ryota ; Oki, Eiji ; Sasaki, Shun ; Hirose, Kosuke ; Jogo, Tomoko ; Edahiro, Keitaro ; Korehisa, Shotaro ; Taniguchi, Daisuke ; Kudo, Kensuke ; Kurashige, Junji ; Sugiyama, Masahiko ; Nakashima, Yuichiro ; Ohgaki, Kippei ; Saeki, Hiroshi ; Maehara, Yoshihiko. / Sarcopenia is an independent predictor of complications after colorectal cancer surgery. :: Surgery today. 2018 ; 巻 48, 番号 2. pp. 151-157.
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title = "Sarcopenia is an independent predictor of complications after colorectal cancer surgery",
abstract = "Purpose: The significance of sarcopenia after colorectal cancer (CRC) resection has only been discussed with relatively small samples or short follow-up periods. This study aimed to clarify the clinical significance of sarcopenia in a large-sample study. Methods: We retrospectively analyzed the relationship between sarcopenia and clinical factors, surgical outcomes, and the survival in 494 patients who underwent CRC surgery between 2004 and 2013. Sarcopenia was defined based on the sex-specific skeletal muscle mass index measured by preoperative computed tomography. Results: Sarcopenia was associated with sex (higher rate of male, P < 0.0001), and low body mass index (P < 0.0001), but not age or tumor stage. Sarcopenia was associated with higher incidence of all postoperative complications (P = 0.02), especially for patients with Clavien–Dindo classification grade ≥2 (CDC; P = 0.0007). Postoperative hospital stays were significantly longer for sarcopenic patients than for non-sarcopenic patients (P = 0.02). In a multivariate analysis, sarcopenia was an independent predictor for postoperative complications (P = 0.01, odds ratio 1.82, 95{\%} confidence interval 1.13–3.00). Among postoperative complications (CDC grade ≥2), sarcopenia was correlated with non-surgical-site infections (P = 0.03). Sarcopenia was not correlated with the overall or recurrence-free survival. Conclusions: Sarcopenia was an independent predictive factor for postoperative complications after CRC surgery.",
author = "Ryota Nakanishi and Eiji Oki and Shun Sasaki and Kosuke Hirose and Tomoko Jogo and Keitaro Edahiro and Shotaro Korehisa and Daisuke Taniguchi and Kensuke Kudo and Junji Kurashige and Masahiko Sugiyama and Yuichiro Nakashima and Kippei Ohgaki and Hiroshi Saeki and Yoshihiko Maehara",
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T1 - Sarcopenia is an independent predictor of complications after colorectal cancer surgery

AU - Nakanishi, Ryota

AU - Oki, Eiji

AU - Sasaki, Shun

AU - Hirose, Kosuke

AU - Jogo, Tomoko

AU - Edahiro, Keitaro

AU - Korehisa, Shotaro

AU - Taniguchi, Daisuke

AU - Kudo, Kensuke

AU - Kurashige, Junji

AU - Sugiyama, Masahiko

AU - Nakashima, Yuichiro

AU - Ohgaki, Kippei

AU - Saeki, Hiroshi

AU - Maehara, Yoshihiko

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose: The significance of sarcopenia after colorectal cancer (CRC) resection has only been discussed with relatively small samples or short follow-up periods. This study aimed to clarify the clinical significance of sarcopenia in a large-sample study. Methods: We retrospectively analyzed the relationship between sarcopenia and clinical factors, surgical outcomes, and the survival in 494 patients who underwent CRC surgery between 2004 and 2013. Sarcopenia was defined based on the sex-specific skeletal muscle mass index measured by preoperative computed tomography. Results: Sarcopenia was associated with sex (higher rate of male, P < 0.0001), and low body mass index (P < 0.0001), but not age or tumor stage. Sarcopenia was associated with higher incidence of all postoperative complications (P = 0.02), especially for patients with Clavien–Dindo classification grade ≥2 (CDC; P = 0.0007). Postoperative hospital stays were significantly longer for sarcopenic patients than for non-sarcopenic patients (P = 0.02). In a multivariate analysis, sarcopenia was an independent predictor for postoperative complications (P = 0.01, odds ratio 1.82, 95% confidence interval 1.13–3.00). Among postoperative complications (CDC grade ≥2), sarcopenia was correlated with non-surgical-site infections (P = 0.03). Sarcopenia was not correlated with the overall or recurrence-free survival. Conclusions: Sarcopenia was an independent predictive factor for postoperative complications after CRC surgery.

AB - Purpose: The significance of sarcopenia after colorectal cancer (CRC) resection has only been discussed with relatively small samples or short follow-up periods. This study aimed to clarify the clinical significance of sarcopenia in a large-sample study. Methods: We retrospectively analyzed the relationship between sarcopenia and clinical factors, surgical outcomes, and the survival in 494 patients who underwent CRC surgery between 2004 and 2013. Sarcopenia was defined based on the sex-specific skeletal muscle mass index measured by preoperative computed tomography. Results: Sarcopenia was associated with sex (higher rate of male, P < 0.0001), and low body mass index (P < 0.0001), but not age or tumor stage. Sarcopenia was associated with higher incidence of all postoperative complications (P = 0.02), especially for patients with Clavien–Dindo classification grade ≥2 (CDC; P = 0.0007). Postoperative hospital stays were significantly longer for sarcopenic patients than for non-sarcopenic patients (P = 0.02). In a multivariate analysis, sarcopenia was an independent predictor for postoperative complications (P = 0.01, odds ratio 1.82, 95% confidence interval 1.13–3.00). Among postoperative complications (CDC grade ≥2), sarcopenia was correlated with non-surgical-site infections (P = 0.03). Sarcopenia was not correlated with the overall or recurrence-free survival. Conclusions: Sarcopenia was an independent predictive factor for postoperative complications after CRC surgery.

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DO - 10.1007/s00595-017-1564-0

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SP - 151

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JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

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