SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

The Genotype to Phenotype Japan (G2P-Japan) Consortium

研究成果: ジャーナルへの寄稿学術誌査読

201 被引用数 (Scopus)

抄録

Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These mutations can affect viral properties such as infectivity and immune resistance. Although the sensitivity of naturally occurring SARS-CoV-2 variants to humoral immunity has been investigated, sensitivity to human leukocyte antigen (HLA)-restricted cellular immunity remains largely unexplored. Here, we demonstrate that two recently emerging mutations in the receptor-binding domain of the SARS-CoV-2 spike protein, L452R (in B.1.427/429 and B.1.617) and Y453F (in B.1.1.298), confer escape from HLA-A24-restricted cellular immunity. These mutations reinforce affinity toward the host entry receptor ACE2. Notably, the L452R mutation increases spike stability, viral infectivity, viral fusogenicity, and thereby promotes viral replication. These data suggest that HLA-restricted cellular immunity potentially affects the evolution of viral phenotypes and that a further threat of the SARS-CoV-2 pandemic is escape from cellular immunity.

本文言語英語
ページ(範囲)1124-1136.e11
ジャーナルCell Host and Microbe
29
7
DOI
出版ステータス出版済み - 7月 14 2021

!!!All Science Journal Classification (ASJC) codes

  • 寄生虫科
  • 微生物学
  • ウイルス学

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