Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system

Noriko Satoh, Yoshihiro Ogawa, Goro Katsuura, Yoshito Numata, Hiroaki Masuzaki, Yasunao Yoshimasa, Kazuwa Nakao

研究成果: Contribution to journalArticle査読

177 被引用数 (Scopus)

抄録

Leptin is an adipocyte-derived blood-borne satiety factor that decreases food intake and increases energy expenditure, thereby leading to a substantial decrease in body weight. To explore the possible roles of the hypothalamic melanocortin system in leptin action, we examined the effects of intracerebroventricular (ICV) injection of leptin with or without SHU9119, a potent antagonist of α-melanocyte stimulating hormone, on food intake, body weight, and mitochondrial uncoupling protein-1 (UCP-1) mRNA expression in the brown adipose tissue (BAT) in rats. A single ICV injection of leptin decreased cumulative food intake and body weight gain, and increased UCP-1 mRNA expression during 3 h at the onset of the dark phase. Inhibition of food intake and body weight change with leptin was reversed by co-injection of SHU9119 in a dose-dependent manner. Co-injection of SHU9119 also inhibited completely the leptin-induced increase in UCP-1 mRNA expression in the BAT. Treatment with SHU9119 alone did not affect food intake, body weight, and UCP-1 mRNA expression in rats. The present study provides evidence that the hypothalamic melanocortin system plays a central role in both satiety effect and sympathetic activation of leptin.

本文言語英語
ページ(範囲)107-110
ページ数4
ジャーナルNeuroscience Letters
249
2-3
DOI
出版ステータス出版済み - 6 19 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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