Schizandrin reverses memory impairment in rats

Nobuaki Egashira, Kouji Kurauchi, Katsunori Iwasaki, Kenichi Mishima, Kensuke Orito, Ryozo Oishi, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.

本文言語英語
ページ(範囲)49-52
ページ数4
ジャーナルPhytotherapy Research
22
1
DOI
出版ステータス出版済み - 1 2008

All Science Journal Classification (ASJC) codes

  • 薬理学

フィンガープリント

「Schizandrin reverses memory impairment in rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル