Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

Tai Hyun Kang, Hyun Ock Pae, Sei Joon Jeong, Ji Chang Yoo, Byung Min Choi, Chang Duk Jun, Hun Taeg Chung, Tomofumi Miyamoto, R. Higuchi, Youn Chul Kim

研究成果: Contribution to journalArticle査読

62 被引用数 (Scopus)

抄録

Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN- γ) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.

本文言語英語
ページ(範囲)400-403
ページ数4
ジャーナルPlanta medica
65
5
DOI
出版ステータス出版済み - 7 8 1999

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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