Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

Tai Hyun Kang, Hyun Ock Pae, Sei Joon Jeong, Ji Chang Yoo, Byung Min Choi, Chang Duk Jun, Hun Taeg Chung, Tomofumi Miyamoto, R. Higuchi, Youn Chul Kim

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)

抜粋

Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN- γ) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.

元の言語英語
ページ(範囲)400-403
ページ数4
ジャーナルPlanta medica
65
発行部数5
DOI
出版物ステータス出版済み - 7 8 1999

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

これを引用

Kang, T. H., Pae, H. O., Jeong, S. J., Yoo, J. C., Choi, B. M., Jun, C. D., ... Kim, Y. C. (1999). Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Planta medica, 65(5), 400-403. https://doi.org/10.1055/s-1999-14014