Screening of a glycopolymer library for GM1 mimetics synthesized by the “carbohydrate module method”

Masanori Nagao, Takeshi Uemura, Tasuku Horiuchi, Yu Hoshino, Yoshiko Miura

研究成果: Contribution to journalArticle査読

抄録

The “carbohydrate module method” is a promising approach for oligosaccharide mimetics using polymeric materials. However, it is difficult to predict the optimal structure for a particular oligosaccharide mimetic, and an efficient strategy for the synthesis and evaluation of glycopolymers is desirable. In this study, a screening of glycopolymers for the “carbohydrate module method” by a combination of photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization and surface plasmon resonance imaging (SPRI) is demonstrated. The facile and fast screening of synthetic glycomimetics was achieved, and the glycopolymer with the optimal structure as a GM1 mimetic strongly interacted with the cholera toxin B subunit.

本文言語英語
ページ(範囲)10871-10874
ページ数4
ジャーナルChemical Communications
57
83
DOI
出版ステータス出版済み - 10 25 2021

All Science Journal Classification (ASJC) codes

  • 触媒
  • 電子材料、光学材料、および磁性材料
  • セラミックおよび複合材料
  • 化学 (全般)
  • 表面、皮膜および薄膜
  • 金属および合金
  • 材料化学

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