Screening of antipsychotic drugs by wide-bore capillary gas chromatography with nitrogen phosphorus detection - Detection levels in plasma

H. Tokunaga, K. Kudo, T. Imamura, N. Jitsufuchi, T. Nagata

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

The detection levels of 12 antipsychotic drugs as ascertained from drug screening were examined in order to rise the screening results effectively for treatment of patients or medico-legal examinations in cases of poisoning. Wide bore capillary gas chromatography with nitrogen phosphorus detection was used for the analysis. The detection limits of drugs in plasma using 3 extraction procedures, single-solvent, 3-step solvent and solid phase extractions were 50 100 ng/ml, 10 200 ng/ml and 5 50 ng/ml, respectively. The detection limits were compared with blood levels previously reported in the literature. Only 4 drugs were detected at the therapeutic level, thioridazine, floropipamide, sultopride and oxypertine using the single- solvent extraction procedure. Using the 3-step solvent extraction procedure, chlorpromazine, levomepromazine and zotepine in addition to the above 4 drugs were detected. Using the solid-phase extraction procedure, 8 of 12 drugs were able to be detected at the therapeutic level, with the exception of perphenazine, haloperidol, bromperidol and nemonapride. These data were proved to be useful for a rapid forensic diagnosis.

本文言語英語
ページ(範囲)196-202
ページ数7
ジャーナルJapanese Journal of Legal Medicine
50
3
出版ステータス出版済み - 8 1 1996

All Science Journal Classification (ASJC) codes

  • 健康政策
  • 法学

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