TY - JOUR
T1 - Screening of Selected Stingless Bee Honey Varieties for ACE2-Spike Protein-Binding Inhibition Activity
T2 - A Potential Preventive Medicine Against SARS-Cov-2 Infection
AU - Arung, Enos Tangke
AU - Ramadhan, Rico
AU - Mandzilkh, Liidza Diana
AU - Santoso, Prasetia Aktavinaldy
AU - Matsumoto, Masako
AU - Nagata, Maki
AU - Kusuma, Irawan Wijaya
AU - Paramita, Swandari
AU - Sukemi,
AU - Yadi,
AU - Takemoto, Naomichi
AU - Amen, Yhiya
AU - Syafrizal,
AU - Shimizu, Kuniyoshi
AU - Tandirogang, Nataniel
N1 - Funding Information:
This study was supported by the Japan-ASEAN Science, Technology and Innovation Platform (JST SICORP Japan, reference no. JPMJSC15H1 granted to Enos Tangke Arung), the Ministry of Research, Technology and Higher Education, Republic of Indonesia, in the Basic Research 2019 scheme (reference no. 198/UN17.41/KL/2019 granted to Enos Tangke Arung), Word Class Research (reference no. 204/UN17.41/KL/2019 granted to Enos Tangke Arung) and the Kyushu University Institute for Asian and Oceanian Studies (Q-AOS) (granted to Kuniyoshi Shimizu).
Publisher Copyright:
© 2022, Penerbit Universiti Sains Malaysia. All rights reserved.
PY - 2022
Y1 - 2022
N2 - The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 samples of honey from 11 species of stingless bees using an angiotensin-converting enzyme 2 (ACE2)-spike protein-binding assay and phytochemical analysis. Ten of the samples showed inhibition above 50% in this assay system. Most of the honey contained tannins, alkaloids, flavonoids, triterpenoids, carotenoids and carbohydrates. Our findings in this in vitro study showed that honey from stingless bees may have a potent effect against SARS-CoV-2 infection by inhibiting the ACE2-spike protein-binding.
AB - The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 samples of honey from 11 species of stingless bees using an angiotensin-converting enzyme 2 (ACE2)-spike protein-binding assay and phytochemical analysis. Ten of the samples showed inhibition above 50% in this assay system. Most of the honey contained tannins, alkaloids, flavonoids, triterpenoids, carotenoids and carbohydrates. Our findings in this in vitro study showed that honey from stingless bees may have a potent effect against SARS-CoV-2 infection by inhibiting the ACE2-spike protein-binding.
UR - http://www.scopus.com/inward/record.url?scp=85140894925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140894925&partnerID=8YFLogxK
U2 - 10.21315/mjms2022.29.5.15
DO - 10.21315/mjms2022.29.5.15
M3 - Article
AN - SCOPUS:85140894925
SN - 1394-195X
VL - 29
SP - 146
EP - 153
JO - Malaysian Journal of Medical Sciences
JF - Malaysian Journal of Medical Sciences
IS - 5
ER -