Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q

F. Takeuchi, Y. Ochiai, M. Serizawa, K. Yanai, N. Kuzuya, H. Kajio, S. Honjo, N. Takeda, Y. Kaburagi, K. Yasuda, S. Shirasawa, Takehiko Sasazuki, N. Kato

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

To systematically evaluate genetic susceptibility to type 2 diabetes (T2D) in "candidate" regions on chromosomes 1q, 3q and 12q, we examined disease association by using a total of 2,083 SNPs in two-step screening; a screening panel comprised 473 cases and 285 controls and an extended (or combined) panel involved 658 cases and 474 controls. For the total interval screened (40.9 Mb), suggestive evidence of association was provided for several annotated gene loci. For example, in the MCF2L2 gene on 3q, a significant association (a nominal P value of 0.00009) was observed when logistic regression analysis was performed for three associated SNPs (rs684846, rs35069869 and rs35368790) that belonged to different LD groups. Also, in the SLC15A4 gene on 12q, rs3765108 showed a marginally significant association with an overall estimated odds ratio of 0.79 (P = 0.001). No significant association was found for known candidate gene loci on 3q, such as ADIPOQ and IGF2BP2. Using the available samples, we have observed disease associations of SNPs derived from two novel gene loci in the Japanese population through high-density searches of diabetes susceptibility in three chromosomal regions. Independent replication will clarify the etiological relevance of these genomic loci to T2D.

元の言語英語
ページ(範囲)314-324
ページ数11
ジャーナルJournal of Human Genetics
53
発行部数4
DOI
出版物ステータス出版済み - 4 1 2008
外部発表Yes

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Type 2 Diabetes Mellitus
Chromosomes
Single Nucleotide Polymorphism
Genes
Genetic Predisposition to Disease
Logistic Models
Odds Ratio
Regression Analysis
Population

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

これを引用

Takeuchi, F., Ochiai, Y., Serizawa, M., Yanai, K., Kuzuya, N., Kajio, H., ... Kato, N. (2008). Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. Journal of Human Genetics, 53(4), 314-324. https://doi.org/10.1007/s10038-008-0254-6

Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. / Takeuchi, F.; Ochiai, Y.; Serizawa, M.; Yanai, K.; Kuzuya, N.; Kajio, H.; Honjo, S.; Takeda, N.; Kaburagi, Y.; Yasuda, K.; Shirasawa, S.; Sasazuki, Takehiko; Kato, N.

:: Journal of Human Genetics, 巻 53, 番号 4, 01.04.2008, p. 314-324.

研究成果: ジャーナルへの寄稿記事

Takeuchi, F, Ochiai, Y, Serizawa, M, Yanai, K, Kuzuya, N, Kajio, H, Honjo, S, Takeda, N, Kaburagi, Y, Yasuda, K, Shirasawa, S, Sasazuki, T & Kato, N 2008, 'Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q', Journal of Human Genetics, 巻. 53, 番号 4, pp. 314-324. https://doi.org/10.1007/s10038-008-0254-6
Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H その他. Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. Journal of Human Genetics. 2008 4 1;53(4):314-324. https://doi.org/10.1007/s10038-008-0254-6
Takeuchi, F. ; Ochiai, Y. ; Serizawa, M. ; Yanai, K. ; Kuzuya, N. ; Kajio, H. ; Honjo, S. ; Takeda, N. ; Kaburagi, Y. ; Yasuda, K. ; Shirasawa, S. ; Sasazuki, Takehiko ; Kato, N. / Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. :: Journal of Human Genetics. 2008 ; 巻 53, 番号 4. pp. 314-324.
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