Second hepatectomy for recurrent hepatocellular carcinoma achieved sustained virological response to interferon therapy for hepatitis C

Eiji Tsujita, Yo Ichi Yamashita, Kazuki Takeishi, Takashi Maeda, Shin Ichiro Takaki, Nanti Mori, Yasuyuki Aisaka, Yoshinari Furukawa, Ken Shirabe, Teruyoshi Ishida, Yoshihiko Maehara

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Background/Aims: Interferon (IFN) improves the prognosis of HCV-related hepatocellular carcinoma (HCC) in patients. However, the effects of IFN therapy for second hepatectomy (Hx) for recurrent HCC have not been established. Methodology: Subjects included 96 patients who underwent a second Hx for recurrence of HCV-related HCC. Forty-four patients received IFN therapy past or postoperatively of the first Hx. Twenty of those patients attained a sustained viral response (SVR). The other 24 were non-responders (NR) and 52 patients who had not received IFN therapy (non-lFN) were classified as the NR/non-IFN group. Results: Overall survival (SVR group vs. NR/non-IFN group: 5-yr, 91.7 vs. 51.0%; p = 0.012) and disease-free survival (SVR group vs. NR/non-IFN group: 3-yr, 64.7 vs. 25.9%; p = 0.006) rates were significantly different in both groups. By multivariate analysis, NR/non-IFN therapy, was the independent risk factor for overall survival (p = 0.025) and disease-free survival (p = 0.006) after second Hx. Conclusions: SVR achieved past or postoperatively of the first Hx of HCV-related HCC significantly inhibits recurrence and consequently improves patient survival after second Hx for recurrent HCC. Patients with SVR to IFN therapy would be good candidates for second Hx for recurrent HCC.

本文言語英語
ページ(範囲)2048-2054
ページ数7
ジャーナルHepato-gastroenterology
60
128
DOI
出版ステータス出版済み - 11 2013

All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 消化器病学

フィンガープリント

「Second hepatectomy for recurrent hepatocellular carcinoma achieved sustained virological response to interferon therapy for hepatitis C」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル