Sedative effects of oral pregabalin premedication on intravenous sedation using propofol target-controlled infusion

Noriko Karube, Shinichi Ito, Saori Sako, Jun Hirokawa, Takeshi Yokoyama

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Purpose: The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respiration, and postanesthetic complications. Methods: Ten healthy young volunteers underwent 1 h of IVS using propofol, three times per subject, on separate days (first time, no pregabalin; second time, pregabalin 100 mg; third time, pregabalin 200 mg). The target blood concentration (CT) of propofol was increased in a stepwise fashion based on the bispectral index (BIS) value. Ramsay’s sedation score (RSS) was determined at each propofol CT. Propofol CT was analyzed at each sedation level. Circulation and respiration during IVS and complications were also verified. Results: Propofol CT was reduced at BIS values of 60 and 70 in both premedicated groups (100 mg: p = 0.043 and 0.041; 200 mg: p = 0.004 and 0.016, respectively) and at a BIS value of 80 in the pregabalin 200 mg group (p < 0.001). Propofol CT was decreased at RSS 4–6 in the pregabalin 100 mg group (RSS 4: p = 0.047; RSS 5: p = 0.007; RSS 6: p = 0.014), and at RSS 3–6 in the pregabalin 200 mg group (RSS 3–5: p < 0.001; RSS 6: p = 0.002). Conclusion: We conclude that oral premedication with pregabalin reduces the amount of propofol required to obtain an acceptable and adequate sedation level.

元の言語英語
ページ(範囲)586-592
ページ数7
ジャーナルJournal of Anesthesia
31
発行部数4
DOI
出版物ステータス出版済み - 8 1 2017

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Premedication
Propofol
Hypnotics and Sedatives
Respiration
Pregabalin
Perioperative Period
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

これを引用

Sedative effects of oral pregabalin premedication on intravenous sedation using propofol target-controlled infusion. / Karube, Noriko; Ito, Shinichi; Sako, Saori; Hirokawa, Jun; Yokoyama, Takeshi.

:: Journal of Anesthesia, 巻 31, 番号 4, 01.08.2017, p. 586-592.

研究成果: ジャーナルへの寄稿記事

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title = "Sedative effects of oral pregabalin premedication on intravenous sedation using propofol target-controlled infusion",
abstract = "Purpose: The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respiration, and postanesthetic complications. Methods: Ten healthy young volunteers underwent 1 h of IVS using propofol, three times per subject, on separate days (first time, no pregabalin; second time, pregabalin 100 mg; third time, pregabalin 200 mg). The target blood concentration (CT) of propofol was increased in a stepwise fashion based on the bispectral index (BIS) value. Ramsay’s sedation score (RSS) was determined at each propofol CT. Propofol CT was analyzed at each sedation level. Circulation and respiration during IVS and complications were also verified. Results: Propofol CT was reduced at BIS values of 60 and 70 in both premedicated groups (100 mg: p = 0.043 and 0.041; 200 mg: p = 0.004 and 0.016, respectively) and at a BIS value of 80 in the pregabalin 200 mg group (p < 0.001). Propofol CT was decreased at RSS 4–6 in the pregabalin 100 mg group (RSS 4: p = 0.047; RSS 5: p = 0.007; RSS 6: p = 0.014), and at RSS 3–6 in the pregabalin 200 mg group (RSS 3–5: p < 0.001; RSS 6: p = 0.002). Conclusion: We conclude that oral premedication with pregabalin reduces the amount of propofol required to obtain an acceptable and adequate sedation level.",
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T1 - Sedative effects of oral pregabalin premedication on intravenous sedation using propofol target-controlled infusion

AU - Karube, Noriko

AU - Ito, Shinichi

AU - Sako, Saori

AU - Hirokawa, Jun

AU - Yokoyama, Takeshi

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N2 - Purpose: The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respiration, and postanesthetic complications. Methods: Ten healthy young volunteers underwent 1 h of IVS using propofol, three times per subject, on separate days (first time, no pregabalin; second time, pregabalin 100 mg; third time, pregabalin 200 mg). The target blood concentration (CT) of propofol was increased in a stepwise fashion based on the bispectral index (BIS) value. Ramsay’s sedation score (RSS) was determined at each propofol CT. Propofol CT was analyzed at each sedation level. Circulation and respiration during IVS and complications were also verified. Results: Propofol CT was reduced at BIS values of 60 and 70 in both premedicated groups (100 mg: p = 0.043 and 0.041; 200 mg: p = 0.004 and 0.016, respectively) and at a BIS value of 80 in the pregabalin 200 mg group (p < 0.001). Propofol CT was decreased at RSS 4–6 in the pregabalin 100 mg group (RSS 4: p = 0.047; RSS 5: p = 0.007; RSS 6: p = 0.014), and at RSS 3–6 in the pregabalin 200 mg group (RSS 3–5: p < 0.001; RSS 6: p = 0.002). Conclusion: We conclude that oral premedication with pregabalin reduces the amount of propofol required to obtain an acceptable and adequate sedation level.

AB - Purpose: The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respiration, and postanesthetic complications. Methods: Ten healthy young volunteers underwent 1 h of IVS using propofol, three times per subject, on separate days (first time, no pregabalin; second time, pregabalin 100 mg; third time, pregabalin 200 mg). The target blood concentration (CT) of propofol was increased in a stepwise fashion based on the bispectral index (BIS) value. Ramsay’s sedation score (RSS) was determined at each propofol CT. Propofol CT was analyzed at each sedation level. Circulation and respiration during IVS and complications were also verified. Results: Propofol CT was reduced at BIS values of 60 and 70 in both premedicated groups (100 mg: p = 0.043 and 0.041; 200 mg: p = 0.004 and 0.016, respectively) and at a BIS value of 80 in the pregabalin 200 mg group (p < 0.001). Propofol CT was decreased at RSS 4–6 in the pregabalin 100 mg group (RSS 4: p = 0.047; RSS 5: p = 0.007; RSS 6: p = 0.014), and at RSS 3–6 in the pregabalin 200 mg group (RSS 3–5: p < 0.001; RSS 6: p = 0.002). Conclusion: We conclude that oral premedication with pregabalin reduces the amount of propofol required to obtain an acceptable and adequate sedation level.

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