Seeking for the endogenous ligands for PPARγ

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)


Peroxisome proliferators-activated receptors gamma (PPARγ) is an isoform of PPARs which are members of the nuclear receptor superfamily and are considered as key sensors of lipid and glucose homeostasis. This ligand-activated transcription factor has been intensively studied for more than a decade and the bona fide endogenous ligand remains unknown. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ 2) is of great interest because it affects gene transcription by binding and activating PPARγ and by covalent addition to transcription factors and signaling molecules. However, the actual concentration of 15d-PGJ2 is several orders of magnitude below the levels required to induce many of the biological reaction attributed to this molecule. This short review will focus on 15d-PGJ2 as a ligand of PPARγ and on other candidates of the endogenous ligand for the receptor.

ジャーナルJournal of Clinical Biochemistry and Nutrition
出版ステータス出版済み - 2005

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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