Selective adsorption of EDA(+)fibronectin and antithronbin III by sufonated polysaccharide

T. Komai, T. Shimizu, K. Miyashita, K. Miyamoto, Masayuki Tokita, N. Kobayashi, E. Shakashita

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

We have reported that selective adsorption of EDA(+)fibronectin (EDA(+)FN) and plasma FN in cryogel using heparin-immobilized absorbents. However, the absorbent could not display the superior selectivity for antithronbin III(ATIII). In this work, we tried to prepare the materials which remains specific affinity for EDAFN except for the adsorbability to ATIII. Gellan was sulfonated chemically and immobilized on surfaces of substrate. Then, their properties were evaluated in vitro. As the results, we have succeeded to prepare material just fit to our purpose. 90% of EDAFN, 20% of total fibronectin and 8% of ATIII in plasma was adsorbed with the gellan sulfate (25% of hydroxy group was substitute).

本文言語英語
ページ(範囲)195-199
ページ数5
ジャーナルJapanese Journal of Artificial Organs
26
1
出版ステータス出版済み - 1月 1 1997

!!!All Science Journal Classification (ASJC) codes

  • 生物理学

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