Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells

Yumiko Matsumura, Takashi Kobayashi, Kenji Ichiyama, Ryoko Yoshida, Masayuki Hashimoto, Tomohito Takimoto, Kentaro Tanaka, Takatoshi Chinen, Takashi Shichita, Tony Wyss-Coray, Katsuaki Sato, Akihiko Yoshimura

研究成果: ジャーナルへの寄稿記事

89 引用 (Scopus)

抄録

Dendritic cells (DCs) induce immunity and immunological tolerance as APCs. It has been shown that DCs secreting IL-10 induce IL-10+ Tr1-type regulatory T (Treg) cells, whereas Foxp3-positive Treg cells are expanded from naive CD4+ T cells by coculturing with mature DCs. However, the regulatory mechanism of expansion of Foxp3+ Treg cells by DCs has not been clarified. In this study, we demonstrated that suppressors of cytokine signaling (SOCS)-3-deficient DCs have a strong potential as Foxp3+ T cell-inducing tolerogenic DCs. SOCS3-/- DCs expressed lower levels of class II MHC, CD40, CD86, and IL-12 than wild-type (WT)-DCs both in vitro and in vivo, and showed constitutive activation of STAT3. Foxp3- effector T cells were predominantly expanded by the priming with WT-DCs, whereas Foxp3+ Treg cells were selectively expanded by SOCS3-/- DCs. Adoptive transfer of SOCS3-/- DCs reduced the severity of experimental autoimmune encephalomyelitis. Foxp3+ T cell expansion was blocked by anti-TGF-β Ab, and SOCS3-/- DCs produced higher levels of TGF-β than WT-DCs, suggesting that TGF-β plays an essential role in the expansion of Foxp3+ Treg cells. These results indicate an important role of SOCS3 in determining on immunity or tolerance by DCs.

元の言語英語
ページ(範囲)2170-2179
ページ数10
ジャーナルJournal of Immunology
179
発行部数4
DOI
出版物ステータス出版済み - 8 15 2007

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Regulatory T-Lymphocytes
Immunosuppression
Dendritic Cells
Cytokines
T-Lymphocytes
Interleukin-10
Immunity
Autoimmune Experimental Encephalomyelitis
Adoptive Transfer
Interleukin-12

All Science Journal Classification (ASJC) codes

  • Immunology

これを引用

Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. / Matsumura, Yumiko; Kobayashi, Takashi; Ichiyama, Kenji; Yoshida, Ryoko; Hashimoto, Masayuki; Takimoto, Tomohito; Tanaka, Kentaro; Chinen, Takatoshi; Shichita, Takashi; Wyss-Coray, Tony; Sato, Katsuaki; Yoshimura, Akihiko.

:: Journal of Immunology, 巻 179, 番号 4, 15.08.2007, p. 2170-2179.

研究成果: ジャーナルへの寄稿記事

Matsumura, Y, Kobayashi, T, Ichiyama, K, Yoshida, R, Hashimoto, M, Takimoto, T, Tanaka, K, Chinen, T, Shichita, T, Wyss-Coray, T, Sato, K & Yoshimura, A 2007, 'Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells', Journal of Immunology, 巻. 179, 番号 4, pp. 2170-2179. https://doi.org/10.4049/jimmunol.179.4.2170
Matsumura, Yumiko ; Kobayashi, Takashi ; Ichiyama, Kenji ; Yoshida, Ryoko ; Hashimoto, Masayuki ; Takimoto, Tomohito ; Tanaka, Kentaro ; Chinen, Takatoshi ; Shichita, Takashi ; Wyss-Coray, Tony ; Sato, Katsuaki ; Yoshimura, Akihiko. / Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. :: Journal of Immunology. 2007 ; 巻 179, 番号 4. pp. 2170-2179.
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AU - Yoshida, Ryoko

AU - Hashimoto, Masayuki

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AU - Tanaka, Kentaro

AU - Chinen, Takatoshi

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AU - Wyss-Coray, Tony

AU - Sato, Katsuaki

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