Selective induction of ΔFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication of ΔFosB and galectin-1 in neuroprotection and neurogenesis

H. Kurushima, M. Ohno, T. Miura, T. Y. Nakamura, H. Horie, T. Kadoya, H. Ooboshi, T. Kitazono, S. Ibayashi, M. Iida, Yusaku Nakabeppu

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

抄録

Transient forebrain ischemia causes selective induction of ΔFosB, an AP-1 (activator protein-1) subunit, in cells within the ventricle wall or those in the dentate gyrus in the rat brain prior to neurogenesis, followed by induction of nestin, a marker for neuronal precursor cells, or galectin-1, a β-galactoside sugar-binding lectin. The adenovirus-mediated expression of FOSB or ΔFosB induced expression of nestin, glial fibrillary acidic protein and galectin-1 in rat embryonic cortical cells. ΔFosB-expressing cells exhibited a significantly higher survival and proliferation after the withdrawal of B27 supplement than the control or FosB-expressing cells. The decline in the ΔFosB expression in the survivors enhanced the MAP2 expression. The expression of ΔFosB in cells within the ventricle wall of the rat brain also resulted in an elevated expression of nestin. We therefore conclude that ΔFosB can promote the proliferation of quiescent neuronal precursor cells, thus enhancing neurogenesis after transient forebrain ischemia.

元の言語英語
ページ(範囲)1078-1096
ページ数19
ジャーナルCell Death and Differentiation
12
発行部数8
DOI
出版物ステータス出版済み - 8 1 2005

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Galectin 1
Neurogenesis
Prosencephalon
Ischemia
Nestin
Brain
Galactosides
Glial Fibrillary Acidic Protein
Dentate Gyrus
Transcription Factor AP-1
Protein Subunits
Neuroprotection
Lectins
Adenoviridae

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

これを引用

Selective induction of ΔFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication of ΔFosB and galectin-1 in neuroprotection and neurogenesis. / Kurushima, H.; Ohno, M.; Miura, T.; Nakamura, T. Y.; Horie, H.; Kadoya, T.; Ooboshi, H.; Kitazono, T.; Ibayashi, S.; Iida, M.; Nakabeppu, Yusaku.

:: Cell Death and Differentiation, 巻 12, 番号 8, 01.08.2005, p. 1078-1096.

研究成果: ジャーナルへの寄稿記事

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abstract = "Transient forebrain ischemia causes selective induction of ΔFosB, an AP-1 (activator protein-1) subunit, in cells within the ventricle wall or those in the dentate gyrus in the rat brain prior to neurogenesis, followed by induction of nestin, a marker for neuronal precursor cells, or galectin-1, a β-galactoside sugar-binding lectin. The adenovirus-mediated expression of FOSB or ΔFosB induced expression of nestin, glial fibrillary acidic protein and galectin-1 in rat embryonic cortical cells. ΔFosB-expressing cells exhibited a significantly higher survival and proliferation after the withdrawal of B27 supplement than the control or FosB-expressing cells. The decline in the ΔFosB expression in the survivors enhanced the MAP2 expression. The expression of ΔFosB in cells within the ventricle wall of the rat brain also resulted in an elevated expression of nestin. We therefore conclude that ΔFosB can promote the proliferation of quiescent neuronal precursor cells, thus enhancing neurogenesis after transient forebrain ischemia.",
author = "H. Kurushima and M. Ohno and T. Miura and Nakamura, {T. Y.} and H. Horie and T. Kadoya and H. Ooboshi and T. Kitazono and S. Ibayashi and M. Iida and Yusaku Nakabeppu",
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AU - Miura, T.

AU - Nakamura, T. Y.

AU - Horie, H.

AU - Kadoya, T.

AU - Ooboshi, H.

AU - Kitazono, T.

AU - Ibayashi, S.

AU - Iida, M.

AU - Nakabeppu, Yusaku

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