Selective suppression of cell growth and programmed cell death-ligand 1 expression in HT1080 fibrosarcoma cells by low molecular weight fucoidan extract

Kiichiro Teruya, Yoshihiro Kusumoto, Hiroshi Eto, Noboru Nakamichi, Sanetaka Shirahata

研究成果: ジャーナルへの寄稿記事

抄録

Low molecular weight fucoidan extract (LMF), prepared by an abalone glycosidase digestion of a crude fucoidan extracted from Cladosiphon novae-caledoniae Kylin, exhibits various biological activities, including anticancer effect. Various cancers express programmed cell death-ligand 1 (PD-L1), which is known to play a significant role in evasion of the host immune surveillance system. PD-L1 is also expressed in many types of normal cells for self-protection. Previous research has revealed that selective inhibition of PD-L1 expressed in cancer cells is critical for successful cancer eradication. In the present study, we analyzed whether LMF could regulate PD-L1 expression in HT1080 fibrosarcoma cells. Our results demonstrated that LMF suppressed PD-L1/PD-L2 expression and the growth of HT1080 cancer cells and had no effect on the growth of normal TIG-1 cells. Thus, LMF differentially regulates PD-L1 expression in normal and cancer cells and could serve as an alternative complementary agent for treatment of cancers with high PD-L1 expression.

元の言語英語
記事番号421
ジャーナルMarine Drugs
17
発行部数7
DOI
出版物ステータス出版済み - 7 19 2019

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Fibrosarcoma
Cell Death
Molecular Weight
Ligands
Growth
Neoplasms
Programmed Cell Death 1 Ligand 2 Protein
Cytoprotection
Glycoside Hydrolases
fucoidan
Digestion
Immune System
Research

All Science Journal Classification (ASJC) codes

  • Drug Discovery

これを引用

Selective suppression of cell growth and programmed cell death-ligand 1 expression in HT1080 fibrosarcoma cells by low molecular weight fucoidan extract. / Teruya, Kiichiro; Kusumoto, Yoshihiro; Eto, Hiroshi; Nakamichi, Noboru; Shirahata, Sanetaka.

:: Marine Drugs, 巻 17, 番号 7, 421, 19.07.2019.

研究成果: ジャーナルへの寄稿記事

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AU - Eto, Hiroshi

AU - Nakamichi, Noboru

AU - Shirahata, Sanetaka

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