Semi-wet peptide/protein array using supramolecular hydrogel

Shigeki Kiyonaka, Kazuki Sada, Ibuki Yoshimura, Seiji Shinkai, Nobuo Kato, Itaru Hamachi

研究成果: ジャーナルへの寄稿記事

486 引用 (Scopus)

抄録

A new semi-wet peptide/protein gel array, in which peptides or proteins were entrapped in the active form, was constructed. The hierarchical structural characteristics of supramolecular hydrogel based on a glycosylated amino acid ester were demonstrated. The gel fibers were self-assembled and stabilized by multiple interactions such as β-sheet-like hydrogen-bonding networks, van der Walls packing and hydrophobic interactions. The spontaneous gel-formation and amphiphilic property of the hydrogel was applied to supramolecular semi-wet peptide/protein gel arrays that were compatible with enzyme activity assays and the screening of enzyme inhibitors.

元の言語英語
ページ(範囲)58-64
ページ数7
ジャーナルNature Materials
3
発行部数1
DOI
出版物ステータス出版済み - 1 1 2004

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Hydrogel
Hydrogels
Peptides
peptides
Gels
gels
proteins
Proteins
enzyme inhibitors
enzyme activity
Enzyme activity
Enzyme Inhibitors
amino acids
Amino acids
esters
Assays
Esters
Hydrogen bonds
Screening
screening

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

これを引用

Kiyonaka, S., Sada, K., Yoshimura, I., Shinkai, S., Kato, N., & Hamachi, I. (2004). Semi-wet peptide/protein array using supramolecular hydrogel. Nature Materials, 3(1), 58-64. https://doi.org/10.1038/nmat1034

Semi-wet peptide/protein array using supramolecular hydrogel. / Kiyonaka, Shigeki; Sada, Kazuki; Yoshimura, Ibuki; Shinkai, Seiji; Kato, Nobuo; Hamachi, Itaru.

:: Nature Materials, 巻 3, 番号 1, 01.01.2004, p. 58-64.

研究成果: ジャーナルへの寄稿記事

Kiyonaka, S, Sada, K, Yoshimura, I, Shinkai, S, Kato, N & Hamachi, I 2004, 'Semi-wet peptide/protein array using supramolecular hydrogel', Nature Materials, 巻. 3, 番号 1, pp. 58-64. https://doi.org/10.1038/nmat1034
Kiyonaka S, Sada K, Yoshimura I, Shinkai S, Kato N, Hamachi I. Semi-wet peptide/protein array using supramolecular hydrogel. Nature Materials. 2004 1 1;3(1):58-64. https://doi.org/10.1038/nmat1034
Kiyonaka, Shigeki ; Sada, Kazuki ; Yoshimura, Ibuki ; Shinkai, Seiji ; Kato, Nobuo ; Hamachi, Itaru. / Semi-wet peptide/protein array using supramolecular hydrogel. :: Nature Materials. 2004 ; 巻 3, 番号 1. pp. 58-64.
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