Sensitive and selective determination of bromisovalum by high-performance liquid chromatography/particle beam mass spectrometry

Takeaki Nagata, Keiko Kudo, Tohru Imamura, Narumi Jitsufuchi

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

A specific procedure using high-performance liquid chromatography/particle beam mass spectrometry (HPLC/PBMS) has facilitated determination of bromisovalum in human plasma and whole blood. Bromisovalum, a sedative and hypnotic, was effectively extracted with SepPak C18 cartridges and selectively determined by HPLC/PBMS of EI mode. An originally synthesized 2-bromohexanoylurea served as the internal standard (IS). The calibration curve was linear over the concentration range 0.5-5.0 μg/g and the lower limit of detection was 0.1 μg/g (10 ng at the time of direct injection). This method could be practically applied to detect bromisovalum in the whole blood of an autopsied individual.

本文言語英語
ページ(範囲)205-211
ページ数7
ジャーナルForensic Science International
74
3
DOI
出版ステータス出版済み - 7 28 1995

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

フィンガープリント

「Sensitive and selective determination of bromisovalum by high-performance liquid chromatography/particle beam mass spectrometry」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル