Sensitivity to heat and radiation of human rectal malignant tissues in Vitro

Masaki Mori, Yoshihiko Maehara, Tetsuya Inoue, Reiji Shimono, Hiroyuki Kuwano, Keizo Sugimachi

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

The sensitivity to heat and radiation of 22 rectal cancer tissues obtained at biopsy was studied using the in vitro succinate dehydrogenase inhibition test. The succinate dehydrogenase activity of tissue fragments was assayed after exposure at 43† C (hyperthermia) for 20 hours, to radiation of 6 Gy, and to both heat (43† C) and radiation (6 Gy). The sensitivity to each treatment was estimated by the percentage of succinate dehydrogenase activity of the treated cells compared with that of control cells. The mean plus or minus standard deviation of succinate dehydrogenase activity after exposure to radiation, heat, and both heat and radiation, was 84.7±12.6 percent, 52.9±20.7 percent, and 46.8 ±20.7 percent, respectively. The succinate dehydrogenase activities of heat-treated cells and both heat- and radiation-treated cells were significantly lower than that of the radiation-treated cells (P<0.01). The succinate dehydrogenase activities of heat plus radiation treated cells were the lowest in tissues from cancer lesions. Although the number was small, there was a correlation between this test and clinical outcome in seven of nine cases. Thus, preoperative therapy of hyperthermia plus radiotherapy is expected to be effective for treating patients with rectal cancer.

本文言語英語
ページ(範囲)590-593
ページ数4
ジャーナルDiseases of the Colon & Rectum
33
7
DOI
出版ステータス出版済み - 7 1 1990

All Science Journal Classification (ASJC) codes

  • 消化器病学

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