Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation

Taichi Ikedo, Hiroharu Kataoka, Manabu Minami, Kosuke Hayashi, Takeshi Miyata, Manabu Nagata, Risako Fujikawa, Masayuki Yokode, Hirohiko Imai, Tetsuya Matsuda, Susumu Miyamoto

研究成果: ジャーナルへの寄稿記事

抄録

Objective: To investigate the association between vascular morphology and the development of intracranial aneurysms (IAs), the morphological changes of intracranial arteries after IA induction were examined using a rodent model. Methods: The vascular morphology of the circle of Willis in rats was visualized at 1 week and at 3 months after IA induction using 7-T magnetic resonance imaging. The following 2 angle parameters were defined: the angle between the parent artery and the daughter arteries (PD angle), and the widening of the daughter arteries (DD angle). The correlations of the angle parameters with IA size and with the number of macrophages infiltrated in the IA wall by immunohistochemistry were examined. Results: Magnetic resonance imaging showed bending of the arteries over time around the predilection site for IAs. The PD angle increased significantly 1 week after IA induction (P < 0.05) and correlated with IA size (P < 0.01). The DD angle did not increase after 1 week, but increased 3 months after IA induction (P < 0.01). The PD angle 1 week after surgery also correlated with the number of infiltrated macrophages in aneurysmal walls (P = 0.01). Conclusions: Sequential inward bending of arterial bifurcations occurred after IA induction in the rat model. The degree of arterial bending correlated with IA development and inflammation in the IA wall, suggesting that the vascular morphology may be strongly associated with IA development through a proinflammatory mechanism.

元の言語英語
ページ(範囲)e361-e366
ジャーナルWorld Neurosurgery
129
DOI
出版物ステータス出版済み - 9 1 2019

Fingerprint

Intracranial Aneurysm
Arteries
Blood Vessels
Macrophages
Magnetic Resonance Imaging
Circle of Willis
Rodentia
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

これを引用

Ikedo, T., Kataoka, H., Minami, M., Hayashi, K., Miyata, T., Nagata, M., ... Miyamoto, S. (2019). Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation. World Neurosurgery, 129, e361-e366. https://doi.org/10.1016/j.wneu.2019.05.153

Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation. / Ikedo, Taichi; Kataoka, Hiroharu; Minami, Manabu; Hayashi, Kosuke; Miyata, Takeshi; Nagata, Manabu; Fujikawa, Risako; Yokode, Masayuki; Imai, Hirohiko; Matsuda, Tetsuya; Miyamoto, Susumu.

:: World Neurosurgery, 巻 129, 01.09.2019, p. e361-e366.

研究成果: ジャーナルへの寄稿記事

Ikedo, T, Kataoka, H, Minami, M, Hayashi, K, Miyata, T, Nagata, M, Fujikawa, R, Yokode, M, Imai, H, Matsuda, T & Miyamoto, S 2019, 'Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation', World Neurosurgery, 巻. 129, pp. e361-e366. https://doi.org/10.1016/j.wneu.2019.05.153
Ikedo, Taichi ; Kataoka, Hiroharu ; Minami, Manabu ; Hayashi, Kosuke ; Miyata, Takeshi ; Nagata, Manabu ; Fujikawa, Risako ; Yokode, Masayuki ; Imai, Hirohiko ; Matsuda, Tetsuya ; Miyamoto, Susumu. / Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation. :: World Neurosurgery. 2019 ; 巻 129. pp. e361-e366.
@article{a29ac89d61134815ab4038ee3f60da96,
title = "Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation",
abstract = "Objective: To investigate the association between vascular morphology and the development of intracranial aneurysms (IAs), the morphological changes of intracranial arteries after IA induction were examined using a rodent model. Methods: The vascular morphology of the circle of Willis in rats was visualized at 1 week and at 3 months after IA induction using 7-T magnetic resonance imaging. The following 2 angle parameters were defined: the angle between the parent artery and the daughter arteries (PD angle), and the widening of the daughter arteries (DD angle). The correlations of the angle parameters with IA size and with the number of macrophages infiltrated in the IA wall by immunohistochemistry were examined. Results: Magnetic resonance imaging showed bending of the arteries over time around the predilection site for IAs. The PD angle increased significantly 1 week after IA induction (P < 0.05) and correlated with IA size (P < 0.01). The DD angle did not increase after 1 week, but increased 3 months after IA induction (P < 0.01). The PD angle 1 week after surgery also correlated with the number of infiltrated macrophages in aneurysmal walls (P = 0.01). Conclusions: Sequential inward bending of arterial bifurcations occurred after IA induction in the rat model. The degree of arterial bending correlated with IA development and inflammation in the IA wall, suggesting that the vascular morphology may be strongly associated with IA development through a proinflammatory mechanism.",
author = "Taichi Ikedo and Hiroharu Kataoka and Manabu Minami and Kosuke Hayashi and Takeshi Miyata and Manabu Nagata and Risako Fujikawa and Masayuki Yokode and Hirohiko Imai and Tetsuya Matsuda and Susumu Miyamoto",
year = "2019",
month = "9",
day = "1",
doi = "10.1016/j.wneu.2019.05.153",
language = "English",
volume = "129",
pages = "e361--e366",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation

AU - Ikedo, Taichi

AU - Kataoka, Hiroharu

AU - Minami, Manabu

AU - Hayashi, Kosuke

AU - Miyata, Takeshi

AU - Nagata, Manabu

AU - Fujikawa, Risako

AU - Yokode, Masayuki

AU - Imai, Hirohiko

AU - Matsuda, Tetsuya

AU - Miyamoto, Susumu

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objective: To investigate the association between vascular morphology and the development of intracranial aneurysms (IAs), the morphological changes of intracranial arteries after IA induction were examined using a rodent model. Methods: The vascular morphology of the circle of Willis in rats was visualized at 1 week and at 3 months after IA induction using 7-T magnetic resonance imaging. The following 2 angle parameters were defined: the angle between the parent artery and the daughter arteries (PD angle), and the widening of the daughter arteries (DD angle). The correlations of the angle parameters with IA size and with the number of macrophages infiltrated in the IA wall by immunohistochemistry were examined. Results: Magnetic resonance imaging showed bending of the arteries over time around the predilection site for IAs. The PD angle increased significantly 1 week after IA induction (P < 0.05) and correlated with IA size (P < 0.01). The DD angle did not increase after 1 week, but increased 3 months after IA induction (P < 0.01). The PD angle 1 week after surgery also correlated with the number of infiltrated macrophages in aneurysmal walls (P = 0.01). Conclusions: Sequential inward bending of arterial bifurcations occurred after IA induction in the rat model. The degree of arterial bending correlated with IA development and inflammation in the IA wall, suggesting that the vascular morphology may be strongly associated with IA development through a proinflammatory mechanism.

AB - Objective: To investigate the association between vascular morphology and the development of intracranial aneurysms (IAs), the morphological changes of intracranial arteries after IA induction were examined using a rodent model. Methods: The vascular morphology of the circle of Willis in rats was visualized at 1 week and at 3 months after IA induction using 7-T magnetic resonance imaging. The following 2 angle parameters were defined: the angle between the parent artery and the daughter arteries (PD angle), and the widening of the daughter arteries (DD angle). The correlations of the angle parameters with IA size and with the number of macrophages infiltrated in the IA wall by immunohistochemistry were examined. Results: Magnetic resonance imaging showed bending of the arteries over time around the predilection site for IAs. The PD angle increased significantly 1 week after IA induction (P < 0.05) and correlated with IA size (P < 0.01). The DD angle did not increase after 1 week, but increased 3 months after IA induction (P < 0.01). The PD angle 1 week after surgery also correlated with the number of infiltrated macrophages in aneurysmal walls (P = 0.01). Conclusions: Sequential inward bending of arterial bifurcations occurred after IA induction in the rat model. The degree of arterial bending correlated with IA development and inflammation in the IA wall, suggesting that the vascular morphology may be strongly associated with IA development through a proinflammatory mechanism.

UR - http://www.scopus.com/inward/record.url?scp=85068087165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068087165&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2019.05.153

DO - 10.1016/j.wneu.2019.05.153

M3 - Article

C2 - 31176059

AN - SCOPUS:85068087165

VL - 129

SP - e361-e366

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

ER -