Serotonin suppresses N-methyl-d-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat

Kazuyuki Murase, Mirjana Randic, Tetsuya Shirasaki, Takashi Nakagawa, Norio Akaike

研究成果: Contribution to journalArticle査読

215 被引用数 (Scopus)

抄録

In acutely isolated spinal dorsal horn neurons of the rat, effects of serotonin (5-hydroxytryptamine, 5-HT) on inward current induced by excitatory amino acids were studied under whole-cell voltage-clamp condition. 5-HT suppressed the response to N-methyl-d-aspartate (NMDA), but not the response to kainate or quisqualate. This inhibitory effect of 5-HT on NMDA response was present at 5-HT concentrations as low as 10-15 M. Although the 5-HT effect exhibited similar pharmacology to the 5-HT1A-type receptors, it was not mimicked by increasing intracellular concentration of adenosine 3′,5′-cyclic monophosphate that is the common second messenger for 5-HT1A receptors in the mammalian central nervous system. Glycine strongly antagonized this inhibitory effect of 5-HT, and 5-HT reduced opening of NMDA-gated single channels recorded from the outside-out membrane patch. These lines of evidence are consistent with a possibility that 5-HT might directly modulate the NMDA receptor-ion channel complex, either by interacting with the regulatory site(s) or by acting on a distinct site.

本文言語英語
ページ(範囲)84-91
ページ数8
ジャーナルBrain Research
525
1
DOI
出版ステータス出版済み - 8 13 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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