Serum BAFF and APRIL levels in patients with PBC

Kiyoshi Migita, Bibigul Ilyassova, Elena F. Kovzel, Alexander Nersesov, Seigo Abiru, Yumi Maeda, Atsumasa Komori, Masahiro Ito, Koji Yano, Hiroshi Yatsuhashi, Shinji Shimoda, Hiromi Ishibashi, Minoru Nakamura

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抜粋

B-cell-activating factor belonging to the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) are known to be involved in the occurrence of autoimmune diseases. We assessed serum levels of these cytokines in PBC patients. Serum BAFF levels were significantly higher in PBC patients than in healthy controls (1253.9 ± 741.4 vs. 722.8 ± 199.2 pg/ml; p < 0.0001) and HCV-infected patients (1253.9 ± 741.4 vs. 871.0 ± 251.1 pg/ml; p = 0.015). Whereas changes in serum APRIL levels were not significant among these groups, there was a significant correlation between BAFF and AST (R = 0.278, p = 0.003) or total bilirubin (R = 0.363, p = 0.0006) in PBC patients. Furthermore, serum BAFF levels were elevated in PBC patients with advanced interface hepatitis. Our data indicate that serum levels of BAFF and APRIL are differentially regulated and serum BAFF levels are significantly elevated in PBC patients. These findings suggest that BAFF may serve as a modulator of the clinical and/or serological manifestation in PBC patients.

元の言語英語
ページ(範囲)217-225
ページ数9
ジャーナルClinical Immunology
134
発行部数2
DOI
出版物ステータス出版済み - 2 1 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

フィンガープリント Serum BAFF and APRIL levels in patients with PBC' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Migita, K., Ilyassova, B., Kovzel, E. F., Nersesov, A., Abiru, S., Maeda, Y., Komori, A., Ito, M., Yano, K., Yatsuhashi, H., Shimoda, S., Ishibashi, H., & Nakamura, M. (2010). Serum BAFF and APRIL levels in patients with PBC. Clinical Immunology, 134(2), 217-225. https://doi.org/10.1016/j.clim.2009.09.007