Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population

The hisayama study

Toshiharu Ninomiya, Noriyuki Kanzaki, Yoichiro Hirakawa, Masahito Yoshinari, Mayu Higashioka, Takanori Honda, Mao Shibata, Satoko Sakata, Daigo Yoshida, Takanori Teramoto, Susumu Takemoto, Shozo Nishimoto, Jun Hata, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

抄録

OBJECTIVE This study investigated the association between serum ethylamine levels as an indicator of L-theanine consumption and the development of type 2 diabetes in a Japanese community. RESEARCH DESIGN AND METHODS A total of 2,253 community-dwelling Japanese individuals aged 40-79 years without diabetes were monitored for 7 years. Serum ethylamine levels were divided into quartiles: ≤0.86, 0.87-2.10, 2.11-5.28, and ≥5.29 ng/mL. Kinetic analysis of serum ethylamine concentrations was performed after ingestion of L-theanine-rich green tea products containing 8 mg of L-theanine by 12 healthy volunteers. RESULTS During follow-up, 282 subjects developed type 2 diabetes. The age- and sexadjusted cumulative incidence of type 2 diabetes decreased significantly with elevating levels of serum ethylamine (P for trend = 0.04). This association remained unchanged after adjusting for potential confounding factors. The multivariableadjusted hazard ratio (HR) for type 2 diabetes was significantly lower in the fourth quartile of serum ethylamine than in the first quartile (HR 0.69, 95% CI 0.49-0.98). This trend of decrease in diabetic risk across serum ethylamine levels was more prominent in middle-aged subjects and in subjects with prediabetes, obesity, or insulin resistance. Kinetic analysis estimated that the minimum concentration at the steady state was >5.90 ng/mL in the case of twice-daily ingestion with an interval of 12 h. CONCLUSIONS Higher serum ethylamine was significantly associated with lower risk of the development of type 2 diabetes in a general Japanese population. The measurement of serum ethylamine concentration would be a useful biomarker for the objective estimation of L-theanine consumption.

元の言語英語
ページ(範囲)1234-1240
ページ数7
ジャーナルDiabetes care
42
発行部数7
DOI
出版物ステータス出版済み - 1 1 2019

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Type 2 Diabetes Mellitus
Serum
Population
Eating
Independent Living
Prediabetic State
theanine
ethylamine
Tea
Insulin Resistance
Healthy Volunteers
Research Design
Obesity
Biomarkers
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

これを引用

Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population : The hisayama study. / Ninomiya, Toshiharu; Kanzaki, Noriyuki; Hirakawa, Yoichiro; Yoshinari, Masahito; Higashioka, Mayu; Honda, Takanori; Shibata, Mao; Sakata, Satoko; Yoshida, Daigo; Teramoto, Takanori; Takemoto, Susumu; Nishimoto, Shozo; Hata, Jun; Kitazono, Takanari.

:: Diabetes care, 巻 42, 番号 7, 01.01.2019, p. 1234-1240.

研究成果: ジャーナルへの寄稿記事

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title = "Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population: The hisayama study",
abstract = "OBJECTIVE This study investigated the association between serum ethylamine levels as an indicator of L-theanine consumption and the development of type 2 diabetes in a Japanese community. RESEARCH DESIGN AND METHODS A total of 2,253 community-dwelling Japanese individuals aged 40-79 years without diabetes were monitored for 7 years. Serum ethylamine levels were divided into quartiles: ≤0.86, 0.87-2.10, 2.11-5.28, and ≥5.29 ng/mL. Kinetic analysis of serum ethylamine concentrations was performed after ingestion of L-theanine-rich green tea products containing 8 mg of L-theanine by 12 healthy volunteers. RESULTS During follow-up, 282 subjects developed type 2 diabetes. The age- and sexadjusted cumulative incidence of type 2 diabetes decreased significantly with elevating levels of serum ethylamine (P for trend = 0.04). This association remained unchanged after adjusting for potential confounding factors. The multivariableadjusted hazard ratio (HR) for type 2 diabetes was significantly lower in the fourth quartile of serum ethylamine than in the first quartile (HR 0.69, 95{\%} CI 0.49-0.98). This trend of decrease in diabetic risk across serum ethylamine levels was more prominent in middle-aged subjects and in subjects with prediabetes, obesity, or insulin resistance. Kinetic analysis estimated that the minimum concentration at the steady state was >5.90 ng/mL in the case of twice-daily ingestion with an interval of 12 h. CONCLUSIONS Higher serum ethylamine was significantly associated with lower risk of the development of type 2 diabetes in a general Japanese population. The measurement of serum ethylamine concentration would be a useful biomarker for the objective estimation of L-theanine consumption.",
author = "Toshiharu Ninomiya and Noriyuki Kanzaki and Yoichiro Hirakawa and Masahito Yoshinari and Mayu Higashioka and Takanori Honda and Mao Shibata and Satoko Sakata and Daigo Yoshida and Takanori Teramoto and Susumu Takemoto and Shozo Nishimoto and Jun Hata and Takanari Kitazono",
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TY - JOUR

T1 - Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population

T2 - The hisayama study

AU - Ninomiya, Toshiharu

AU - Kanzaki, Noriyuki

AU - Hirakawa, Yoichiro

AU - Yoshinari, Masahito

AU - Higashioka, Mayu

AU - Honda, Takanori

AU - Shibata, Mao

AU - Sakata, Satoko

AU - Yoshida, Daigo

AU - Teramoto, Takanori

AU - Takemoto, Susumu

AU - Nishimoto, Shozo

AU - Hata, Jun

AU - Kitazono, Takanari

PY - 2019/1/1

Y1 - 2019/1/1

N2 - OBJECTIVE This study investigated the association between serum ethylamine levels as an indicator of L-theanine consumption and the development of type 2 diabetes in a Japanese community. RESEARCH DESIGN AND METHODS A total of 2,253 community-dwelling Japanese individuals aged 40-79 years without diabetes were monitored for 7 years. Serum ethylamine levels were divided into quartiles: ≤0.86, 0.87-2.10, 2.11-5.28, and ≥5.29 ng/mL. Kinetic analysis of serum ethylamine concentrations was performed after ingestion of L-theanine-rich green tea products containing 8 mg of L-theanine by 12 healthy volunteers. RESULTS During follow-up, 282 subjects developed type 2 diabetes. The age- and sexadjusted cumulative incidence of type 2 diabetes decreased significantly with elevating levels of serum ethylamine (P for trend = 0.04). This association remained unchanged after adjusting for potential confounding factors. The multivariableadjusted hazard ratio (HR) for type 2 diabetes was significantly lower in the fourth quartile of serum ethylamine than in the first quartile (HR 0.69, 95% CI 0.49-0.98). This trend of decrease in diabetic risk across serum ethylamine levels was more prominent in middle-aged subjects and in subjects with prediabetes, obesity, or insulin resistance. Kinetic analysis estimated that the minimum concentration at the steady state was >5.90 ng/mL in the case of twice-daily ingestion with an interval of 12 h. CONCLUSIONS Higher serum ethylamine was significantly associated with lower risk of the development of type 2 diabetes in a general Japanese population. The measurement of serum ethylamine concentration would be a useful biomarker for the objective estimation of L-theanine consumption.

AB - OBJECTIVE This study investigated the association between serum ethylamine levels as an indicator of L-theanine consumption and the development of type 2 diabetes in a Japanese community. RESEARCH DESIGN AND METHODS A total of 2,253 community-dwelling Japanese individuals aged 40-79 years without diabetes were monitored for 7 years. Serum ethylamine levels were divided into quartiles: ≤0.86, 0.87-2.10, 2.11-5.28, and ≥5.29 ng/mL. Kinetic analysis of serum ethylamine concentrations was performed after ingestion of L-theanine-rich green tea products containing 8 mg of L-theanine by 12 healthy volunteers. RESULTS During follow-up, 282 subjects developed type 2 diabetes. The age- and sexadjusted cumulative incidence of type 2 diabetes decreased significantly with elevating levels of serum ethylamine (P for trend = 0.04). This association remained unchanged after adjusting for potential confounding factors. The multivariableadjusted hazard ratio (HR) for type 2 diabetes was significantly lower in the fourth quartile of serum ethylamine than in the first quartile (HR 0.69, 95% CI 0.49-0.98). This trend of decrease in diabetic risk across serum ethylamine levels was more prominent in middle-aged subjects and in subjects with prediabetes, obesity, or insulin resistance. Kinetic analysis estimated that the minimum concentration at the steady state was >5.90 ng/mL in the case of twice-daily ingestion with an interval of 12 h. CONCLUSIONS Higher serum ethylamine was significantly associated with lower risk of the development of type 2 diabetes in a general Japanese population. The measurement of serum ethylamine concentration would be a useful biomarker for the objective estimation of L-theanine consumption.

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U2 - 10.2337/dc18-2655

DO - 10.2337/dc18-2655

M3 - Article

VL - 42

SP - 1234

EP - 1240

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 7

ER -